Evidence map›Paper›PMID 38012348›Full record

ArticleJournal, genetic engineering & biotechnology2023

Dual action of epigallocatechin-3-gallate in virus-induced cell Injury.

Ahmed Mostafa, Gomaa Mostafa-Hedeab, Hany Abdelfattah Elhady, Esraa Ahmed Mohamed, Abozer Y Eledrdery, Sager Holyl Alruwaili, Ahmed Mohamed Al-Abd, Abdou Kamal Allayeh

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal, genetic engineering & biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Ahmed Mostafa *Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA. AElsayed@txbiomed.org.ORCID http://orcid.org/0000-0002-2878-5714
Gomaa Mostafa-Hedeab *Pharmacology Department and Health Research Unit, Medical College, Jouf University, 11564, Skaka, Saudi Arabia. gomaa@ju.edu.sa.
Hany Abdelfattah ElhadySurgery Department, Medical College, Jouf University, 11564, Sakaka, Saudi Arabia.
Esraa Ahmed MohamedVirology Department, Nawah Scientific Co, Almokattam Mall, Street 9, Egypt, 11562, El Mokattam, Egypt.
Abozer Y EledrderyDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf Uni-Versity, 11564, Sakaka, Saudi Arabia.
Sager Holyl AlruwailiDepartment of Surgery, Orthopedic Division, College of Medicine, Jouf University, 11564, Sakaka, Saudi Arabia.
Ahmed Mohamed Al-AbdPharmacology Department, Medical and Clinical Research Institute, National Research Centre, Giza, 12622, Egypt.
Abdou Kamal Allayeh *Water Pollution Department, Virology Laboratory, National Research Centre, Dokki, 12622, Giza, Egypt.
Jouf University · SANational Research Centre · EGTexas Biomedical Research Institute · US

Funding

Al Jouf University DSR2022-RG-0152
6 · The paper itself

Abstract

backgroundViral infections cause damage and long-term injury to infected human tissues, demanding therapy with antiviral and wound healing medications. Consequently, safe phytochemical molecules that may control viral infections with an ability to provide wound healing to viral-induced tissue injuries, either topically or systemically, are advantageous. Herein, we hypothesized that epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, might be effective as a wound healing, antiviral, and antifibrotic therapy.

resultsThe antiviral activities of EGCG against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Herpes simplex virus type 2 (HSV-2) as well as its wound healing activities against different monolayer tissue (continuous and primary) systems were investigated. Consider its possible wound-healing advantages as well. To determine the safe concentrations of EGCG in green monkey kidney (Vero) and Vero-E6 cell lines, MTT assay was performed and showed high CC

conclusionsThe EGCG has proven to be an efficient antiviral against SARS-CoV-2 and HSV-2, as well as a wound-healing phytochemical. We assume that EGCG may be a promising option for slowing the course of acute cellular damage induced by systemic (Coronavirus Disease 2019 (COVID-19)) or topical (HSV-2) viral infections.

Indexed as

Antiviral activityCellular injuryCOVID-19EGCGGreen tea extractHerpes simplex virusWound healing

Identifiers

PMID38012348
PMCPMC10682343
OpenAlexW4389070442

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.