Evidence map›Paper›PMID 38014131›Full record

ArticlebioRxiv : the preprint server for biology2023

Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells.

Daniel Maxim Iascone, Xue Zhang, Patricia Bafford, Clementina Mesaros, Yogev Sela, Samuel Hofbauer, Shirley L Zhang, Kieona Cook, Pavel Pivarshev, Ben Z Stanger and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Daniel Maxim IasconeHoward Hughes Medical Institute, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8629-7639
Xue ZhangAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104.
Patricia BaffordAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104.
Clementina MesarosDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Yogev SelaAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104.
Samuel HofbauerDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Shirley L ZhangHoward Hughes Medical Institute, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kieona CookDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Pavel PivarshevHoward Hughes Medical Institute, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ben Z StangerAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0003-0410-4037
Stewart AndersonDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Chi V DangAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104.
Amita SehgalHoward Hughes Medical Institute, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7354-9641
Howard Hughes Medical Institute · USThe Wistar Institute · USChildren's Hospital of Philadelphia · USTranslational Therapeutics (United States) · USUniversity of Pennsylvania · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3M
Specification of Interneurons of the Cerebral CortexR01MH066912 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANDERSON, STEWART A · 2003 to 2020
$5.7M
MYC--TRANSCRIPTION AND INTERACTION WITH P107R01CA051497 · NCI · WISTAR INSTITUTE · PI DANG, CHI V. · 1995 to 2025
$5.3M
Cycling in a circadian circuitR37NS048471 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, AMITA · 2015 to 2021
$2.7M
Coupling between circadian rhythms and redox signaling in stem cell differentiation and adult neurogenesisF32MH125600 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI IASCONE, DANIEL MAXIM · 2020 to 2023
$216k
Determining the importance of temporal regulation of the blood-brain barrierK99HL147212 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ZHANG, SHIRLEY · 2019 to 2021
$206k
NCI NIH HHS R01 CA051497NHLBI NIH HHS K99 HL147212NIEHS NIH HHS P30 ES013508NIMH NIH HHS F32 MH125600NIMH NIH HHS R01 MH066912NINDS NIH HHS R37 NS048471
6 · The paper itself

Abstract

Crosstalk between cellular metabolism and circadian rhythms is a fundamental building block of multicellular life, and disruption of this reciprocal communication could be relevant to degenerative disease, including cancer. Here, we investigated whether maintenance of circadian rhythms depends upon specific metabolic pathways, particularly in the context of cancer. We found that in adult mouse fibroblasts, ATP levels were a major contributor to overall levels of a clock gene luciferase reporter, although not necessarily to the strength of circadian cycling. In contrast, we identified significant metabolic control of circadian function in an

Identifiers

PMID38014131
PMCPMC10680562
OpenAlexW4388620614

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.