ArticlebioRxiv : the preprint server for biology2023
The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.
Open access · greenAbstract readPreprint
In one paragraph
Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 12 citations in OpenAlex.
- Cathepsin-mediated regulation of alpha-synuclein in Parkinson's disease: a Mendelian randomization study.Frontiers in aging neuroscience · 2024Article
- Cathepsins and neurological diseases: a Mendelian randomization study.Frontiers in neuroscience · 2024Article
Corrections and comments
- Updated by
Authors and funding
34 authors at 10 institutions in 5 countries.
Jace Jones-TabahMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Kathy HeMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Konstantin SenkevichMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Nathan KarpilovskyMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Ghislaine DeyabMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Yuting CousineauDepartment of Neurology and Neurosurgery, McGill University, Montréal, Canada.
Daria NikanorovaResearch Department, Bioinformatics Institute, Saint-Petersburg, Russia.
Taylor GoldsmithEarly Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Esther Del Cid PelliteroMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Carol X-Q ChenEarly Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Wen LuoEarly Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Zhipeng YouEarly Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Narges AbdianEarly Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Isabella PietrantonioMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Thomas GoiranMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Jamil AhmadMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Jennifer A RuskeyMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Farnaz AsayeshMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Dan SpiegelmanMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Cheryl WatersDepartment of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, NY, USA.
Oury MonchiDepartment of Neurology and Neurosurgery, McGill University, Montréal, Canada.
Yves DauvilliersNational Reference Center for Narcolepsy, Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Montpellier, France.
Nicolas DupréNeuroscience Axis, CHU de Québec - Université Laval, Quebec City, G1V 4G2, Canada.
Irina MiliukhinaInstitute of the Human Brain of RAS, St. Petersburg, Russia.
Alla TimofeevaFirst Pavlov State Medical University of St. Petersburg, Saint-Petersburg, Russia.
Anton EmelyanovFirst Pavlov State Medical University of St. Petersburg, Saint-Petersburg, Russia.
Sofya PchelinaFirst Pavlov State Medical University of St. Petersburg, Saint-Petersburg, Russia.
Lior GreenbaumInstitute of the Human Brain of RAS, St. Petersburg, Russia.
Sharon Hassin-BaerSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Roy N AlcalayDepartment of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, NY, USA.
Austen MilnerwoodDepartment of Neurology and Neurosurgery, McGill University, Montréal, Canada.
Thomas M DurcanEarly Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Ziv Gan-OrMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Edward A FonMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.
Montreal Neurological Institute and Hospital · CAFirst Pavlov State Medical University of St. Petersburg · RUColumbia University Irving Medical Center · USMcGill University · CATel Aviv University · ILBioinformatics Institute · RUInstitute of the Human Brain · RUInstitut Universitaire de Gériatrie de Montréal · CAUniversité de Montpellier · FRUniversité Laval · CA
Funding
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MGenetic characterization of atypical parkinsonismZIANS003154 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SCHOLZ, SONJA · 2016 to 2025
$15.4MThe role of glucocerebrosidase in Parkinson's diseaseK02NS080915 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALCALAY, ROY · 2012 to 2016
$905kGenome sequencing of Lewy Body Dementia and Frontotemporal Dementia: a public resource for the study of Alzheimers disease and related dementiasZIAAG000935 · NIA · NATIONAL INSTITUTE ON AGING · PI TRAYNOR, BRYAN · 2017 to 2025
$771kIntramural NIH HHS ZIA AG000935Intramural NIH HHS ZIA NS003154NCATS NIH HHS UL1 TR000040NINDS NIH HHS K02 NS080915
Abstract
Variants in the
Indexed as
alpha-synucleincathepsin BGBAiPSClysosomeParkinson’s disease
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.