Evidence map›Paper›PMID 38014168›Full record

ArticlebioRxiv : the preprint server for biology2023

Suppressing DNMT3a Alleviates the Intrinsic Epigenetic Barrier for Optic Nerve Regeneration and Restores Vision in Adult Mice.

Wai Lydia Tai, Kin-Sang Cho, Emil Kriukov, Ajay Ashok, Xuejian Wang, Aboozar Monavarfeshani, Wenjun Yan, Yingqian Li, Timothy Guan, Joshua R Sanes and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. microPublication biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Wai Lydia TaiSchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Kin-Sang ChoSchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Emil KriukovSchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Ajay AshokSchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Xuejian WangSchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Aboozar MonavarfeshaniDepartment of Cellular and Molecular Biology, Center for Brain Science, Harvard University, MA, USA.
Wenjun YanDepartment of Cellular and Molecular Biology, Center for Brain Science, Harvard University, MA, USA.
Yingqian LiSchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Timothy GuanSchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Joshua R SanesDepartment of Cellular and Molecular Biology, Center for Brain Science, Harvard University, MA, USA.
Petr BaranovSchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Dong Feng ChenSchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Massachusetts Eye and Ear Infirmary · USHarvard University · USWeifang Medical University · CN

Funding

VISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Patricia Ann D'Amore · 1985 to 2026
$25.5M
Innate and Adaptive Immunity in the Pathogenesis of GlaucomaR01EY031696 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Dong Feng Chen, Jianzhu Chen · 2021 to 2026
$5.2M
Histone and DNA methyltransferases in optic nerve regenerationR21EY033882 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI CHEN, DONG FENG · 2022 to 2023
$542k
HIGH THROUGHPUT SINGLE CELL TRANSCRIPTOMIC APPROACH TO IDENTIFY SUSCEPTIBLE CELL TYPES AND GENE EXPRESSION CHANGES IN HUMAN GLAUCOMAR21EY032219 · NEI · HARVARD UNIVERSITY · PI SANES, JOSHUA R · 2021 to 2022
$460k
NEI NIH HHS P30 EY003790NEI NIH HHS R01 EY031696NEI NIH HHS R21 EY032219NEI NIH HHS R21 EY033882
6 · The paper itself

Abstract

The limited regenerative potential of the optic nerve in adult mammals presents a major challenge for restoring vision after optic nerve trauma or disease. The mechanisms of this regenerative failure are not fully understood

Identifiers

PMID38014168
PMCPMC10680854
OpenAlexW4388802737

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.