Evidence map›Paper›PMID 38014177›Full record

ArticlebioRxiv : the preprint server for biology2023

IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus.

Mehmet Hakan Guney, Karthika Nagalekshmi, Sean Matthew McCauley, Claudia Carbone, Ozkan Aydemir, Jeremy Luban

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mehmet Hakan GuneyProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Karthika NagalekshmiProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-5732-3631
Sean Matthew McCauleyProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Claudia CarboneProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-2420-8629
Ozkan AydemirProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Jeremy LubanProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0001-5650-4054
University of Massachusetts Chan Medical School · USBroad Institute · US

Funding

CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral DynamicsU54AI170856 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI WALTHER H MOTHES · 2022 to 2026
$34.4M
The HUSH complex in HIV-1 latencyR37AI147868 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI JEREMY LUBAN · 2019 to 2026
$6.4M
NIAID NIH HHS R37 AI147868NIAID NIH HHS U54 AI170856
6 · The paper itself

Abstract

Antiretroviral therapy (ART) suppresses HIV-1 viremia and prevents progression to AIDS. Nonetheless, chronic inflammation is a common problem for people living with HIV-1 on ART. One possible cause of inflammation is ongoing transcription from HIV-1 proviruses, whether or not the sequences are competent for replication. Previous work has shown that intron-containing RNA expressed from the HIV-1 provirus in primary human blood cells, including CD4

Identifiers

PMID38014177
PMCPMC10680824
OpenAlexW4388792931

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.