Evidence map›Paper›PMID 38014183›Full record

ArticlebioRxiv : the preprint server for biology2023

Axon development is regulated at genetic and proteomic interfaces between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hub.

Jonathan Amezquita, Muriel Desbois, Karla J Opperman, Joseph S Pak, Elyse L Christensen, Nikki T Nguyen, Karen Diaz-Garcia, Melissa A Borgen, Brock Grill

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jonathan AmezquitaCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Muriel DesboisCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Karla J OppermanCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Joseph S PakCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Elyse L ChristensenMolecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA, USA.
Nikki T NguyenCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Karen Diaz-GarciaCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Melissa A BorgenFlorida Institute of Technology, Department of Biomedical Engineering and Sciences, Melbourne, USA.
Brock GrillCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.ORCID 0000-0002-0379-3267
University of Washington · USFlorida Institute of Technology · USKeele University · GB

Funding

Mechanisms of synapse formation and axon termination in C. elegansR01NS072129 · NINDS · UNIVERSITY OF MINNESOTA · PI GRILL, BROCK · 2011 to 2024
$8.0M
Molecular genetic mechanisms of opioid receptor signalingR01DA048036 · NIDA · SEATTLE CHILDREN'S HOSPITAL · PI Brock Grill, Kirill A. Martemyanov · 2019 to 2026
$5.8M
NIDA NIH HHS R01 DA048036NINDS NIH HHS R01 NS072129
6 · The paper itself

Abstract

Integrin signaling plays important roles in development and disease. An adhesion signaling network called the integrin adhesome has been principally defined using bioinformatics and proteomics. To date, the adhesome has not been studied using integrated proteomic and genetic approaches. Here, proteomic studies in

Indexed as

adhesomeaxon developmentaxon outgrowthaxon terminationgeneticsgrowth coneintegrinkindlinneurobehavioral deficitneurodevelopmental disorderproteomicstalin

Identifiers

PMID38014183
PMCPMC10680716
OpenAlexW4388731552

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.