Evidence map›Paper›PMID 38014312›Full record

ArticlebioRxiv : the preprint server for biology2023

The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme.

Irina Sbornova, Emilie van der Sande, Snezana Milosavljevic, Elvis Amurrio, Steven D Burbano, Prosun Das, Helen Do, Janet L Fisher, Porschderek Kargbo, Janvi Patel and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Irina SbornovaDepartment of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201.
Emilie van der SandeDepartment of Ophthalmology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.
Snezana MilosavljevicDepartment of Pharmacology, Physiology & Neuroscience, University of South Carolina School of Medicine, Garners Ferry Rd, Columbia, SC.
Elvis AmurrioDepartment of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201.
Steven D BurbanoDepartment of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201.
Prosun DasDepartment of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201.
Helen DoDepartment of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201.
Janet L FisherDepartment of Pharmacology, Physiology & Neuroscience, University of South Carolina School of Medicine, Garners Ferry Rd, Columbia, SC.
Porschderek KargboDepartment of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201.
Janvi PatelDepartment of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201.
Latarsha PorcherDepartment of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201.
Chris I De ZeeuwThe Netherlands Institute for Neuroscience (NIN), Royal Dutch Academy of Art & Science (KNAW), Meibergdreef 47, Amsterdam, The Netherlands.
Magda A Meester-SmoorDepartment of Ophthalmology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.
Beerend H J WinkelmanDepartment of Ophthalmology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.
Caroline C W KlaverDepartment of Ophthalmology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.
Ana PocivavsekDepartment of Pharmacology, Physiology & Neuroscience, University of South Carolina School of Medicine, Garners Ferry Rd, Columbia, SC.ORCID 0000-0002-3817-3201
Michy P KellyDepartment of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201.
University of Maryland, Baltimore · USNetherlands Institute for Neuroscience · NLUniversity of South Carolina · USErasmus MC · NLRadboud University Nijmegen · NL

Funding

Pharmacologic Inhibition of PDE11A for Age-Related Memory DisordersR01AG067836 · NIA · MONTCLAIR STATE UNIVERSITY · PI HOFFMAN, CHARLES S., KELLY, MICHY PATRICE · 2020 to 2024
$3.6M
Role of Cyclic Nucleotide Signaling in Age-Related Decline of Social MemoriesR01AG061200 · NIA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KELLY, MICHY PATRICE · 2019 to 2023
$3.1M
Kynurenic Acid, Sleep and CognitionR01NS102209 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI POCIVAVSEK, ANA · 2017 to 2021
$1.6M
NEUROSCIENCEF30MH010322 · NIMH · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI CHEN, PING-SUN · 1992 to 1997
–
NIA NIH HHS R01 AG061200NIA NIH HHS R01 AG067836NIMH NIH HHS F30 MH010322NINDS NIH HHS R01 NS102209
6 · The paper itself

Abstract

Recently, a Y727C variant in the dual-specific 3',5'-cyclic nucleotide phosphodiesterase 11A (PDE11A-Y727C) was linked to increased sleep quality and reduced myopia risk in humans. Given the well-established role that the PDE11 substrates cAMP and cGMP play in eye physiology and sleep, we determined if 1) PDE11A protein is expressed in the retina or other eye segments in mouse, 2) PDE11A-Y7272C affects catalytic activity and/or subcellular compartmentalization more so than the nearby suicide-associated PDE11A-M878V variant, and 3)

Identifiers

PMID38014312
PMCPMC10680747
OpenAlexW4388751982

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.