SynthesisJournal of the American Heart Association2023
Varying Definitions of Carotid Intima-Media Thickness and Future Cardiovascular Disease: A Systematic Review and Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Effect of Oral Hypoglycaemic Agents on Carotid Artery Intima-Media Thickness in Patients With Cardiovascular Disease and/or Diabetes-A Systematic Review.Endocrinology, diabetes & metabolism · 2025Pooled it
- Cholesterol accumulation in monocytes is associated with the severity of diabetic complications and the efficacy of glycemic control interventions in patients with type 2 diabetes.Journal of diabetes investigation · 2026Article
- Beyond blood pressure: carotid intima-media thickness uncovers subclinical atherosclerosis in normotensive adults with type 2 diabetes in Sub-Saharan Africa.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Predictive threshold value of peak exercise systolic blood pressure for carotid atherosclerosis among the healthy middle-aged population in China.Preventive medicine reports · 2026Article
- Carotid Intima-Media Thickness and Atherogenic Indices in Idiopathic Pulmonary Fibrosis: Evidence of Subclinical Atherosclerosis.Life (Basel, Switzerland) · 2026Article
- Stress and cardiovascular disease: Testing a vigilance pathway in two contemporary theories.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Association of coronary artery calcium and carotid intima-media thickness with white matter hyperintensity.Medicine · 2026Article
- Article
- Metabolic dysfunction-associated steatotic liver disease is associated with vascular dysfunction in type 1 diabetes.Cardiovascular diabetology · 2026Article
- Multiomics insights into eating time patterns and cardiovascular risk among Chinese children.Nature communications · 2026Article
- Sudomotor dysfunction reflects early atherosclerosis risk in adults with type 1 diabetes.Scientific reports · 2026Article
- Subclinical atherosclerosis in rheumatoid arthritis: a case cohort analysis from ELSA-Brasil.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- Association of Dietary Glycemic Index and Glycemic Load With Proatherogenic Factors and Carotid Intima-Media Thickness in Patients With Metabolic Syndrome.Journal of nutrition and metabolism · 2026Article
- Evidence of early subclinical atherosclerosis in women with exercise-induced hypothalamic amenorrhea.Human reproduction open · 2026Article
- Investigation of the subclinical atherosclerosis risk in patients with migraine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Cardiovascular inflammaging: Mechanisms, consequences, and therapeutic perspectives.Cell reports. Medicine · 2025Review
- Future of Families: Cardiovascular Health Among Young Adults Cohort Study: Rationale, Key Questions, Study Design, and Participant Characteristics.Journal of the American Heart Association · 2025Article
- Kolmogorov-Arnold Networks for predicting carotid intima-media thickness in cardiovascular risk assessment.Scientific reports · 2025Article
- Carotid intima-media thickness, cardiovascular disease, and risk factors in 29,000 UK Biobank adults.American journal of preventive cardiology · 2025Article
- Predicting Cognitive Impairment in Elderly Patients with HFpEF: Development of a Simple Clinical Risk Score.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarotid intima-media thickness (cIMT) has been widely used as a predictor of future cardiovascular disease (CVD); however, various definitions of cIMT exist. This study provides a systematic review and meta-analysis of the associations between different cIMT definitions and CVD. METHODS AND
resultsA systematic review of the different cIMT definitions used in prospective cohort studies was performed. The relationships between cIMT of different definitions (common carotid artery IMT [CCA-IMT], internal carotid artery IMT [ICA-IMT], combined segments [combined-IMT], mean CCA-IMT, and maximum CCA-IMT) with future stroke, myocardial infarction (MI), and CVD events were analyzed using random effects models. Among 2287 articles, 18 articles (14 studies) with >10 different cIMT definitions were identified and included in our meta-analysis. After adjusting for age and sex, a 1-SD increase in CCA-IMT was associated with future stroke (hazard ratio [HR], 1.32 [95% CI, 1.27-1.38]), MI (HR, 1.27 [95% CI, 1.22-1.33]), and CVD events (HR, 1.28 [95% CI, 1.19-1.37]). A 1-SD increase in ICA-IMT was related to future stroke (HR, 1.25 [95% CI, 1.11-1.42]) and CVD events (HR, 1.25 [95% CI, 1.04-1.50]) but not MI (HR, 1.26 [95% CI, 0.98-1.61]). A 1-SD increase in combined-IMT was associated with future stroke (HR, 1.30 [95% CI, 1.08-1.57]) and CVD events (HR, 1.36 [95% CI, 1.23-1.49]). Maximum CCA-IMT was more strongly related than mean CCA-IMT with risk of MI, and both measures were similarly associated with stroke and CVD events.
conclusionsCombined-IMT is more strongly associated with CVD events compared with single-segment cIMT definitions. Maximum CCA-IMT shows a stronger association with MI than mean CCA-IMT. Further research is warranted to validate our findings and to standardize the cIMT measurement protocol, as well as to explore underlying mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.