Evidence map›Paper›PMID 38017021›Full record

ArticleScientific reports2023

Characterization of the TCRβ repertoire of peripheral MR1-restricted MAIT cells in psoriasis vulgaris patients.

Maja Jirouš Drulak, Zvonimir Grgić, Vera Plužarić, Marija Šola, Teuta Opačak-Bernardi, Barbara Viljetić, Kristina Glavaš, Maja Tolušić-Levak, Vlatka Periša, Martina Mihalj and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Maja Jirouš DrulakDepartment of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia. mjirous@mefos.hr.
Zvonimir GrgićDepartment of Laboratory Medicine and Pharmacy, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Vera PlužarićDepartment of Laboratory Medicine and Pharmacy, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Marija ŠolaDepartment of Dermatology and Venerology, University Hospital Osijek, Osijek, Croatia.
Teuta Opačak-BernardiDepartment of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Barbara ViljetićDepartment of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Kristina GlavašDepartment of Transfusion Medicine, University Hospital Osijek, Osijek, Croatia.
Maja Tolušić-LevakDepartment of Dermatology and Venerology, University Hospital Osijek, Osijek, Croatia.
Vlatka PerišaDepartment of Internal Medicine and History of Medicine, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Martina MihaljDepartment of Dermatology and Venerology, University Hospital Osijek, Osijek, Croatia.
Mario ŠtefanićDepartment of Nuclear Medicine and Oncology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia. mstefanic@mefos.hr.
Stana TokićDepartment of Laboratory Medicine and Pharmacy, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia. stokic@mefos.hr.
University of Osijek · HR

Funding

Croatian Science Foundation UIP-2019-04-3494Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia IP15-2020-MEFOS
6 · The paper itself

Abstract

Psoriasis vulgaris (PV) is an inflammatory skin disease largely driven by aberrant αβT cells. Mucosal-associated invariant T (MAIT) cells, which constitute the largest circulating innate-like αβT cell community in human adults, are characterized by a semi-invariant TCRVα7.2 receptor and MR1-restricted affinity toward microbial metabolites. Limited MAIT TCRα diversity is complemented by a more variable TCRβ repertoire, but its footprint in the MAIT repertoire of PV patients has never been tested. Here, we used bulk TCRSeq, MiXCR, VDJTools, and Immunarch pipelines to decipher and compare TCRβ clonotypes from flow-sorted, peripheral TCRVα7.2

Indexed as

Mucosal-Associated Invariant T CellsPsoriasisAdultHistocompatibility Antigens Class IHumansMinor Histocompatibility AntigensMucous MembraneReceptors, Antigen, T-Cell, alpha-betaT-Lymphocyte SubsetsHistocompatibility Antigens Class IMinor Histocompatibility AntigensMR1 protein, humanReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID38017021
PMCPMC10684872
OpenAlexW4389079444

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.