Evidence map›Paper›PMID 38018087›Full record

ReviewExpert review of gastroenterology & hepatology2023

Noninvasive electrical neuromodulation for gastrointestinal motility disorders.

Jieyun Yin, Jiande Dz Chen

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of gastroenterology & hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Vagus nerve neuromodulation: A promising method for treating gastrointestinal dysmotility.World journal of gastrointestinal pharmacology and therapeutics · 2025
    Article
  7. Review
  8. Article
  9. Transcutaneous Vagal Nerve Stimulation for Gastrointestinal Disorders.Journal of translational gastroenterology · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jieyun YinTranstimulation Research Inc, Oklahoma City, OK, USA.
Jiande Dz ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor MI, USA.
University of Michigan–Ann Arbor · US

Funding

Functional Neural Circuits of Stomach-Brain InteroceptionR01AT011665 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, JIANDE, LIU, ZHONGMING · 2021 to 2025
$2.8M
Home-based transcutaneous electrical acustimulation for abdominal painUH3NS115108 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, JIANDE · 2022 to 2024
$1.9M
Use of novel MRI technology to study pathophysiology diabetic gastroparesisR01DK131524 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, JIANDE, WILEY, JOHN W · 2021 to 2025
$1.9M
Wearable Transcutaneous Electrical Acustimulation for GastroparesisR44AT011380 · NCCIH · TRANSTIMULATION RESEARCH, INC. · PI YIN, JIEYUN NONE · 2020 to 2021
$1.5M
NCCIH NIH HHS R01 AT011665NCCIH NIH HHS R44 AT011380NIDDK NIH HHS R01 DK131524NINDS NIH HHS UH3 NS115108
6 · The paper itself

Abstract

introductionGastrointestinal motility disorders are highly prevalent without satisfactory treatment. noninvasive electrical neuromodulation is an emerging therapy for treating various gastrointestinal motility disorders. AREAS COVERED: In this review, several emerging noninvasive neuromodulation methods are introduced, including transcutaneous auricular vagal nerve stimulation, percutaneous auricular vagal nerve stimulation, transcutaneous cervical vagal nerve stimulation, transcutaneous electrical acustimulation, transabdominal interference stimulation, tibial nerve stimulation, and translumbosacral neuromodulation therapy. Their clinical applications in the most common gastrointestinal motility are discussed, including gastroesophageal reflux disease, functional dyspepsia, gastroparesis, functional constipation, irritable bowel syndrome, and fecal incontinence. PubMed database was searched from 1995 to June 2023 for relevant articles in English. EXPERT OPINION: Noninvasive neuromodulation is effective and safe in improving both gastrointestinal symptoms and dysmotility; it can be used when pharmacotherapy is ineffective. Future directions include refining the methodology, improving device development and understanding mechanisms of action.

Indexed as

Fecal IncontinenceGastrointestinal DiseasesGastroparesisTranscutaneous Electric Nerve StimulationConstipationGastrointestinal MotilityHumansbrain-gut axiselectrical stimulationGastrointestinal motility disordernoninvasive neuromodulationvagus nerve

Identifiers

PMID38018087
PMCPMC10842705
OpenAlexW4389149115

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.