Evidence map›Paper›PMID 38018376›Full record

SynthesisCancer medicine2023

Updated systematic review of the effects of exercise on understudied health outcomes in cancer survivors.

Kathleen M Sturgeon, Dieuwertje E Kok, Ian R Kleckner, Kristin A Guertin, Jessica McNeil, Traci L Parry, Diane K Ehlers, Andrew Hamilton, Kathryn Schmitz, Kristin L Campbell and 1 more

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. BeyondFrontiers in pain research (Lausanne, Switzerland) · 2025
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Pilot trial testing the effects of exercise on chemotherapy-induced peripheral neurotoxicity (CIPN) and the interoceptive brain system.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Functional limitations among adult cancer survivors in the United States.Journal of cancer survivorship : research and practice · 2026
    Article
  16. Article
  17. Article
  18. Step count and symptom severity during cancer treatment using the Symptom Care at Home digital platform.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 4 countries.

Kathleen M SturgeonDepartment of Public Health Sciences, College of Medicine, Penn State University, Hershey, Pennsylvania, USA.ORCID 0000-0001-9602-7897
Dieuwertje E KokDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
Ian R KlecknerDepartment of Pain & Translational Symptom Science, School of Nursing, University of Maryland Baltimore, Baltimore, Maryland, USA.
Kristin A GuertinDepartment of Public Health Sciences, University of Connecticut Health, Storrs, Connecticut, USA.
Jessica McNeilDepartment of Kinesiology, School of Health and Human Sciences, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.
Traci L ParryDepartment of Kinesiology, School of Health and Human Sciences, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.ORCID 0000-0003-2957-4537
Diane K EhlersDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic Arizona, Phoenix, Arizona, USA.
Andrew HamiltonOregon Health & Science University, Library, Portland, Oregon, USA.
Kathryn SchmitzDivision of Hematology/Oncology, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-2400-2935
Kristin L CampbellDepartment of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.
Kerri Winters-StoneDivision of Oncological Sciences, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
University of North Carolina at Greensboro · USMayo Clinic in Arizona · USOregon Health & Science University · USPennsylvania State University · USUniversity of British Columbia · CAUniversity of Connecticut · USUniversity of Maryland, Baltimore · USUniversity of Pittsburgh · USWageningen University & Research · NL

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI CHERYL LYNN WILLMAN · 1985 to 2026
$151.3M
URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Transdisciplinary Research in Energetics and Cancer (TREC) Training GrantR25CA203650 · NCI · YALE UNIVERSITY · PI IRWIN, MELINDA L · 2016 to 2025
$2.9M
The Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy, Inflammation, and Interoceptive Brain CircuitryK07CA221931 · NCI · UNIVERSITY OF ROCHESTER · PI KLECKNER, IAN ROBERT · 2018 to 2022
$795k
NCI NIH HHS K07 CA221931NCI NIH HHS P30 CA015083NCI NIH HHS R25 CA203650NCI NIH HHS UG1 CA189961NIH HHS K07CA221931NIH HHS R25CA203650
6 · The paper itself

Abstract

introductionThe American College of Sports Medicine provided guidelines for exercise prescriptions in cancer survivors for specific cancer- and treatment-related health outcomes. However, there was insufficient evidence to generate exercise prescriptions for 10 health outcomes of cancer treatment. We sought to update the state of evidence.

methodsWe conducted a systematic review of these 10 understudied health outcomes (bone health, sleep, cardiovascular function, chemotherapy-induced peripheral neuropathy (CIPN), cognitive function, falls and balance, nausea, pain, sexual function, and treatment tolerance) and provided an update of evidence.

resultsWhile the evidence base for each outcome has increased, there remains insufficient evidence to generate exercise prescriptions. Common limitations observed across outcomes included: variability in type and quality of outcome measurement tools, variability in definitions of the health outcomes, a lack of phase III trials, and a majority of trials investigating breast or prostate cancer survivors only.

conclusionWe identified progress in the field of exercise oncology for several understudied cancer- and treatment-related health outcomes. However, we were not able to generate exercise prescriptions due to continued insufficient evidence base. More work is needed to prescribe exercise as medicine for these understudied health outcomes, and our review highlights several strategies to aid in research acceleration within these areas of exercise oncology.

Indexed as

Cancer SurvivorsNeoplasmsProstatic NeoplasmsExerciseExercise TherapyHumansMaleQuality of LifeTreatment Outcomebonecardiovascularchemotherapy-induced peripheral neuropathycognitionfallsnauseaneoplasmpainsexual functionsleeptreatment tolerance

Identifiers

PMID38018376
PMCPMC10757127
OpenAlexW4389145411

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.