Evidence map›Paper›PMID 38018471›Full record

ArticleHypertension (Dallas, Tex. : 1979)2024

Striatin Gene Variants Are Associated With Salt Sensitivity of Blood Pressure by Mechanisms That Differ in Women and Men.

Shadi K Gholami, Mahyar Heydarpour, Jonathan S Williams, Luminita H Pojoga, Gail K Adler, Gordon H Williams, Jose R Romero

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Genetic factors contributing to atherosclerosis.Current opinion in cardiology · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shadi K GholamiDivision of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
Mahyar HeydarpourDivision of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-5741-367X
Jonathan S WilliamsDivision of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0001-7152-765X
Luminita H PojogaDivision of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-9448-6333
Gail K AdlerDivision of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0003-3506-7347
Gordon H WilliamsDivision of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-4804-1093
Jose R RomeroDivision of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0001-8225-0772
Brigham and Women's Hospital · US

Funding

SCOR MOLECULAR GENETICS OF HYPERTENSIONP50HL055000 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WILLIAMS, GORDON H · 1996 to 2005
$13.5M
Salt Sensitive Hypertension and StriatinR01HL144779 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WILLIAMS, GORDON H · 2019 to 2022
$3.3M
Caveolin-1 and vascular dysfunctionR01HL104032 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI POJOGA, LUMINITA · 2010 to 2014
$2.1M
Aldosteron, Intracellular Leukocyte Magnesium and Inflammation in DiabetesR01HL096518 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROMERO, JOSE R · 2009 to 2012
$1.9M
Striatin, Aldosterone and HypertensionR56HL114765 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WILLIAMS, GORDON H · 2018 to 2018
$838k
Aldosterone/mineralocorticoid receptor responses to biologic sex and salt intake: Role of Lysine Specific Demethylase 1 (LSD1)R56HL166263 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI POJOGA, LUMINITA · 2023 to 2023
$834k
NHLBI NIH HHS P50 HL055000NHLBI NIH HHS R01 HL096518NHLBI NIH HHS R01 HL104032NHLBI NIH HHS R01 HL144779NHLBI NIH HHS R56 HL114765NHLBI NIH HHS R56 HL166263
6 · The paper itself

Abstract

backgroundSalt sensitivity of blood pressure (SSBP) is a substantial risk factor for cardiovascular morbidity and mortality. Striatin (STRN) is critical for estrogen and aldosterone nongenomic signaling. However, the role of biological sex on the SSBP phenotype associated with STRN gene variants remains unexplored.

methodData from 1306 subjects participating in the Hypertensive Pathotype (HyperPATH) Consortium were used to identify STRN gene single-nucleotide variants associated with SSBP. Haploblock analysis revealed a novel diplotype in the upstream regulatory region of STRN (rs888083 and rs6744560), with 31% of subjects being homozygous for the risk diplotype.

resultsIndividuals homozygous for the risk diplotype had significantly greater SSBP than nonrisk diplotypes (

conclusionIn women, the primary driver of SSBP is increased aldosterone, while in men, it is reduced renal plasma flow responses. Thus, despite a common hypertensive phenotype (SSBP) in both sexes, the specific treatment approaches might differ to increase therapeutic gain and mitigate adverse effects. These genetic- and sex-based observational results require confirmation in a prospective clinical study.

Indexed as

AldosteroneHypertensionBlood PressureCalmodulin-Binding ProteinsFemaleHumansMaleMembrane ProteinsNerve Tissue ProteinsNucleotidesProspective StudiesSodiumSodium Chloride, DietaryAldosteroneCalmodulin-Binding ProteinsMembrane ProteinsNerve Tissue ProteinsNucleotidesSodiumSodium Chloride, DietarySTRN protein, humanaldosteroneestrogenshumanshypertensionrenal plasma flow

Identifiers

PMID38018471
PMCPMC10843568
OpenAlexW4389143601

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.