Evidence map›Paper›PMID 38018500›Full record

ArticleeLife2023

The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A.

Daniel Muñoz-Reyes, Levi J McClelland, Sandra Arroyo-Urea, Sonia Sánchez-Yepes, Juan Sabín, Sara Pérez-Suárez, Margarita Menendez, Alicia Mansilla, Javier García-Nafría, Stephen Sprang and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. FDA Drug Repurposing Uncovers Modulators of Dopamine DJournal of medicinal chemistry · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Daniel Muñoz-ReyesDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry 'Blas Cabrera', CSIC, Madrid, Spain.
Levi J McClellandCenter for Biomolecular Structure and Dynamics, and Division of Biological Sciences, University of Montana, Missoula, United States.
Sandra Arroyo-UreaInstitute for Biocomputation and Physics of Complex Systems (BIFI) and Laboratorio de Microscopías Avanzadas (LMA), University of Zaragoza, Zaragoza, Spain.
Sonia Sánchez-YepesDepartment of Neurobiology, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Juan SabínAFFINImeter Scientific & Development team, Software 4 Science Developments, Santiago de Compostela, Spain.
Sara Pérez-SuárezDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry 'Blas Cabrera', CSIC, Madrid, Spain.
Margarita MenendezDepartment of Biological Physical-Chemisty, Institute of Physical-Chemistry 'Blas Cabrera', CSIC, Madrid, Spain.
Alicia MansillaDepartment of Neurobiology, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Javier García-NafríaInstitute for Biocomputation and Physics of Complex Systems (BIFI) and Laboratorio de Microscopías Avanzadas (LMA), University of Zaragoza, Zaragoza, Spain.
Stephen SprangCenter for Biomolecular Structure and Dynamics, and Division of Biological Sciences, University of Montana, Missoula, United States.
Maria Jose Sanchez-BarrenaDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry 'Blas Cabrera', CSIC, Madrid, Spain.ORCID 0000-0002-5986-1804
Consejo Superior de Investigaciones Científicas · ESUniversidad de Zaragoza · ESUniversity of Montana · USInstituto Ramón y Cajal de Investigación Sanitaria · ESUniversidad de Alcalá · ESUniversidade de Santiago de Compostela · ES

Funding

Surveillance genome sequencing to detect SARS-CoV-2 virus variants in MontanaP30GM140963 · NIGMS · UNIVERSITY OF MONTANA · PI BOWLER, BRUCE E · 2021 to 2025
$6.9M
Mechanism of G protein Activation by Ric-8A - competitive revision of R01GM105993R01GM105993 · NIGMS · UNIVERSITY OF MONTANA · PI SPRANG, STEPHEN R · 2013 to 2020
$2.8M
NIGMS NIH HHS P30 GM140963NIGMS NIH HHS R01 GM105993NIH HHS P30GM140963NIH HHS R01GM105993
6 · The paper itself

Abstract

The neuronal calcium sensor 1 (NCS-1), an EF-hand Ca

Indexed as

CalciumGuanine Nucleotide Exchange FactorsMolecular ChaperonesNeuronal Calcium-Sensor ProteinsNeuropeptidesPhosphorylationSignal TransductionCalciumfrequenin calcium sensor proteinsGuanine Nucleotide Exchange FactorsMolecular ChaperonesNeuronal Calcium-Sensor ProteinsNeuropeptidesbiochemistrycalcium signalingchemical biologyE. coliguanine nucleotide exchangemolecular biophysicsmolecular chaperonephosphorylationprotein-protein interactionstructural biologysynapse function regulation

Identifiers

PMID38018500
PMCPMC10732572
OpenAlexW4389142433

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.