SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta-analysis.
Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Personality and mortality risk: A systematic review and meta-analysis of longitudinal data.Journal of personality and social psychology · 2026Pooled it
- Personality and cardiovascular mortality risk: a multi-cohort analysis in individuals with and without pre-existing cardiovascular disease.Journal of behavioral medicine · 2025Pooled it
- Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Improving conscientiousness through a smartphone app and telecoaching intervention: insights from multiple sclerosis and healthy aging samples.Journal of neurology · 2025Trial
- A Taxonomy of Data Synthesis.Personality & social psychology bulletin · 2026Article
- Wellbeing trajectories and dementia risk among Mexican-origin adults living in the U.S.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- A coordinated analysis of bidirectional associations between life satisfaction and cognitive function.Journal of personality and social psychology · 2026Article
- Using Photovoice to investigate the lived experiences of family care partners of people living with dementia: What supports their well-being in a care relationship?Frontiers in public health · 2026Article
- Association between neuroticism and brain-wide structural outcomes: Mediation by vascular and mental conditions.Psychological medicine · 2025Article
- Trends over 45 years in personality traits among older populations.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Association of neuroticism with incident dementia and cognitive function: 26-year follow-up of EPIC-Norfolk study.Age and ageing · 2025Article
- Personality as mechanism: An integrative model of five-factor model personality traits as a mechanism between earlier life factors and cognitive aging.Current opinion in psychology · 2025Review
- Understanding Interactions Between Life Satisfaction and Genetic Predisposition on Risk of Alzheimer's Disease up to 14 Years Later: Findings From the UK Biobank.International journal of geriatric psychiatry · 2025Article
- Identifying risk factors for Alzheimer's disease from multivariate longitudinal clinical data using temporal pattern mining.BMC bioinformatics · 2025Article
- Mechanical Properties of the Cortex in Older Adults and Relationships With Personality Traits.Human brain mapping · 2025Article
- Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease.Neurology · 2024Observational
- Personality and Transition From Mild Cognitive Impairment to Normal Cognition vs Dementia.Journal of the American Medical Directors Association · 2024Observational
- Examining the Role of Neuroticism Polygenic Risk in Late Life Cognitive Change: A UK Biobank Study.Behavioral sciences (Basel, Switzerland) · 2024Article
- A Coordinated Data Analysis of Four Studies Exploring Age Differences in Social Interactions and Loneliness During a Global Pandemic.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- ΔJournal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
introductionThe extent to which the Big Five personality traits and subjective well-being (SWB) are discriminatory predictors of clinical manifestation of dementia versus dementia-related neuropathology is unclear.
methodsUsing data from eight independent studies (N
resultsSynthesized and individual study results indicate that high neuroticism and negative affect and low conscientiousness, extraversion, and positive affect were associated with increased risk of long-term dementia diagnosis. There were no consistent associations with neuropathology. DISCUSSION: This multistudy project provides robust, conceptually replicated and extended evidence that psychosocial factors are strong predictors of dementia diagnosis but not consistently associated with neuropathology at autopsy. HIGHLIGHTS: N(+), C(-), E(-), PA(-), and NA(+) were associated with incident diagnosis. Results were consistent despite self-report versus clinical diagnosis of dementia. Psychological factors were not associated with neuropathology at autopsy. Individuals with higher conscientiousness and no diagnosis had less neuropathology. High C individuals may withstand neuropathology for longer before death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.