Evidence map›Paper›PMID 38019293›Full record

ReviewArchives of virology2023

Characteristics and mechanisms of latency-reversing agents in the activation of the human immunodeficiency virus 1 reservoir.

Zhujiao Zhou, Yashuang Jiang, Xinyu Zhong, Jingyi Yang, Geng Yang

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Archives of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhujiao ZhouDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, China.
Yashuang JiangDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, China.
Xinyu ZhongDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, China.
Jingyi YangDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, China.
Geng YangDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, China. yangg@zucc.edu.cn.ORCID http://orcid.org/0000-0003-1139-4802
Hangzhou City University

Funding

Medical Science and Technology Project of Zhejiang Province 2020KY101Medical Technology and Education of Zhejiang Province of China Gran No. 2019KY361National Natural Science Foundation of China Grant No. 81802975Natural Science Foundation of Zhejiang Province Grant No. LY18H180010
6 · The paper itself

Abstract

The "Shock and Kill" method is being considered as a potential treatment for eradicating HIV-1 and achieving a functional cure for acquired immunodeficiency syndrome (AIDS). This approach involves using latency-reversing agents (LRAs) to activate human immunodeficiency virus (HIV-1) transcription in latent cells, followed by treatment with antiviral drugs to kill these cells. Although LRAs have shown promise in HIV-1 patient research, their widespread clinical use is hindered by side effects and limitations. In this review, we categorize and explain the mechanisms of these agonists in activating HIV-1 in vivo and discuss their advantages and disadvantages. In the future, combining different HIV-1 LRAs may overcome their respective shortcomings and facilitate a functional cure for HIV-1.

Indexed as

Acquired Immunodeficiency SyndromeHIV-1Antiviral AgentsHumansAntiviral Agents

Identifiers

PMID38019293
OpenAlexW4389143497

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.