ArticleMagma (New York, N.Y.)2024
Liver T1 and T2 mapping in a large cohort of healthy subjects: normal ranges and correlation with age and sex.
Article in Magma (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Water-T1, PDFF, and T2* mapping of the liver using chemical shift-encoded MOLLI.Abdominal radiology (New York) · 2026Article
- Liver Tissue Mapping in Transfusion-Dependent β-Thalassemia: Reproducibility and Clinical Insights from Multiparametric MRI.Diagnostics (Basel, Switzerland) · 2025Article
- Accelerated free-breathing abdominal T2 mapping with deep learning reconstruction of radial turbo spin-echo data.Magnetic resonance in medicine · 2025Article
- T1 Mapping of the Abdomen, From theAJR. American journal of roentgenology · 2025Review
- Fat-separated T1 mapping for liver function analysis on gadoxetic acid-enhanced MR imaging: 2D two-point Dixon Look-Locker inversion recovery sequence for differentiation of Child-Pugh class B/C from Child-Pugh class A/chronic liver disease.Quantitative imaging in medicine and surgery · 2025Article
- Correlation between cardiac and hepatic native T1 value and myocardial late gadolinium enhancement in children with Kawasaki disease.Quantitative imaging in medicine and surgery · 2025Article
- Liver T1 mapping in Fontan patients and patients with biventricular congenital heart disease - insights into the effects of venous congestions on diffuse liver disease.The international journal of cardiovascular imaging · 2025Article
- Positive Correlation between Lipin-1 and Lipin-2 Expressions and Hepatic T1 Values in IUGR Rats.Current medical imaging · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe established normal ranges for native T1 and T2 values in the human liver using a 1.5 T whole-body imager (General Electric) and we evaluated their variation across hepatic segments and their association with age and sex. MATERIALS AND
methodsOne-hundred healthy volunteers aged 20-70 years (50% females) underwent MRI. Modified Look-Locker inversion recovery and multi-echo fast-spin-echo sequences were used to measure hepatic native global and segmental T1 and T2 values, respectively.
resultsT1 and T2 values exhibited good intra- and inter-observer reproducibility (coefficient of variation < 5%). T1 value over segment 4 was significantly lower than the T1 values over segments 2 and 3 (p < 0.0001). No significant regional T2 variability was detected. Segmental and global T1 values were not associated with age or sex. Global T2 values were independent from age but were significantly lower in males than in females. The lower and upper limits of normal for global T1 values were, respectively, 442 ms and 705 ms. The normal range for global T2 values was 35 ms-54 ms in males and 39 ms-54 ms in females. DISCUSSION: Liver T1 and T2 mapping is feasible and reproducible and the provided normal ranges may help to establish diagnosis and progression of various liver diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.