Evidence map›Paper›PMID 38020713›Full record

ArticleMedComm2023

Single-cell transcriptomic atlas of distinct early immune responses induced by SARS-CoV-2 Proto or its variants in rhesus monkey.

Yun Yang, Tingfu Du, Wenhai Yu, Yanan Zhou, Chengyun Yang, Dexuan Kuang, Junbin Wang, Cong Tang, Haixuan Wang, Yuan Zhao and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yun YangNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Tingfu DuNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.ORCID https://orcid.org/0000-0002-9814-0081
Wenhai YuNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Yanan ZhouNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Chengyun YangNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Dexuan KuangNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Junbin WangNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Cong TangNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Haixuan WangNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Yuan ZhaoNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Hao YangNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Qing HuangNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Daoju WuNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Bai LiNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Qiangming SunNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Hongqi LiuNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.
Shuaiyao LuNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.ORCID https://orcid.org/0000-0003-1675-9735
Xiaozhong PengNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical School Kunming China.ORCID https://orcid.org/0000-0002-9592-9554

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection play a critical role in the pathogenesis and outcome of coronavirus disease 2019 (COVID-19). However, the dynamic profile of immune responses postinfection by SARS-CoV-2 variants of concern (VOC) is not fully understood. In this study, peripheral blood mononuclear cells single-cell sequencing was performed to determine dynamic profiles of immune response to Prototype, Alpha, Beta, and Delta in a rhesus monkey model. Overall, all strains induced dramatic changes in both cellular subpopulations and gene expression levels at 1 day postinfection (dpi), which associated function including adaptive immune response, innate immunity, and IFN response. COVID-19-related genes revealed different gene profiles at 1 dpi among the four SARS-CoV-2 strains, including genes reported in COVID-19 patients with increased risk of autoimmune disease and rheumatic diseases. Delta-infected animal showed inhibition of translation pathway. B cells, T cells, and monocytes showed much commonality rather than specificity among the four strains. Monocytes were the major responders to SARS-CoV-2 infection, and the response lasted longer in Alpha than the other strains. Thus, this study reveals the early immune responses induced by SARS-CoV-2 Proto or its variants in nonhuman primates, which is important information for controlling rapidly evolving viruses.

Indexed as

COVID‐19immune responsenonhuman primatePBMCsSARS‐CoV‐2single‐cell sequencing

Identifiers

PMID38020713
PMCPMC10661830

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.