Evidence map›Paper›PMID 38021296›Full record

ArticlePhotoacoustics2023

Quantification of prefrontal cortical neuronal ensembles following conditioned fear learning in a Fos-LacZ transgenic rat with photoacoustic imaging

James I Matchynski, Timothy S Cilley, Nareen Sadik, Kassem M Makki, Min Wu, Rayyan Manwar, Alexander R Woznicki, Srinivasu Kallakuri, Cynthia L Arfken, Bruce T Hope and 3 more

Open access · goldAbstract read
In one paragraph

Article in Photoacoustics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

James I MatchynskiDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
Timothy S CilleyDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
Nareen SadikDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
Kassem M MakkiJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.
Min WuJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.
Rayyan ManwarUniversity of Illinois at Chicago, Department of Bioengineering, Chicago, IL, USA.
Alexander R WoznickiJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.
Srinivasu KallakuriDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
Cynthia L ArfkenDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
Bruce T HopeThe National Institute on Drug Abuse (NIDA), Intramural Research Program, Baltimore, MD, USA.
Kamran AvanakiUniversity of Illinois at Chicago, Department of Bioengineering, Chicago, IL, USA.
Alana C ContiDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
Shane A PerrineDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
Wayne State University · USJohn D. Dingell VA Medical Center · USUniversity of Illinois Chicago · USNational Institute on Drug Abuse · US

Funding

In vivo photoacoustic imaging of prefrontal cortex in rats undergoing fentanyl self-administrationR21DA052657 · NIDA · WAYNE STATE UNIVERSITY · PI AVANAKI, KAMRAN, PERRINE, SHANE ALAN · 2021 to 2022
$415k
Novel method to quantify conditioned fear-based neuronal activity in rat brain in vivo using high-resolution photoacoustic imagingF30MH122093 · NIMH · WAYNE STATE UNIVERSITY · PI MATCHYNSKI, JAMES · 2020 to 2023
$200k
NIDA NIH HHS R21 DA052657NIMH NIH HHS F30 MH122093
6 · The paper itself

Abstract

Understanding the neurobiology of complex behaviors requires measurement of activity in the discrete population of active neurons, neuronal ensembles, which control the behavior. Conventional neuroimaging techniques ineffectively measure neuronal ensemble activity in the brain

Indexed as

Fear-conditioningFos-LacZ transgenic ratFunctional imagingMedial prefrontal cortexMolecular imagingNeuronal ensemblesOptoacoustic imagingPhotoacoustic imaging

Identifiers

PMID38021296
PMCPMC10658601
OpenAlexW4386200222

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.