Evidence map›Paper›PMID 38025652›Full record

ArticleEuropean heart journal open2023

Invariant natural killer T cells and incidence of first-time coronary events: a nested case-control study.

Lukas Tomas, Pernilla Katra, Wiaam Badn, Linda Andersson, Jan Nilsson, Alexandru Schiopu, Daniel Engelbertsen, Isabel Gonçalves, Eva Bengtsson, Harry Björkbacka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lukas TomasDepartment of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-214 28, Malmö, Sweden.
Pernilla KatraDepartment of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-214 28, Malmö, Sweden.ORCID https://orcid.org/0000-0002-5563-0494
Wiaam BadnDepartment of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-214 28, Malmö, Sweden.
Linda AnderssonDepartment of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-214 28, Malmö, Sweden.
Jan NilssonDepartment of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-214 28, Malmö, Sweden.ORCID https://orcid.org/0000-0002-9752-7479
Alexandru SchiopuDepartment of Translational Medicine, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0002-7587-5050
Daniel EngelbertsenDepartment of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-214 28, Malmö, Sweden.
Isabel GonçalvesDepartment of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-214 28, Malmö, Sweden.
Eva BengtssonDepartment of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-214 28, Malmö, Sweden.
Harry BjörkbackaDepartment of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-214 28, Malmö, Sweden.
Lund University · SEMalmö University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Invariant natural killer T (iNKT) cells, a T cell subset that is CD1d-restricted and expresses a semi-invariant T cell receptor, have been proposed to contribute to dyslipidaemia-driven cardiovascular disease due to their ability to specifically recognize lipid antigens. Studies in mice have attributed pro-atherogenic properties to iNKT cells, but studies in humans investigating associations of iNKT cells with incident coronary events (CE) are lacking. Methods and results: Here, we used flow cytometry to enumerate circulating iNKT cells (CD3 Conclusion: Our findings indicate that animal studies suggesting an atherosclerosis-promoting role for iNKT cells may not translate to human cardiovascular disease as our data show an association between high circulating numbers of DN iNKT cells and decreased risk of incident CE.

Indexed as

Case-control studyCoronary artery diseaseInflammationInvariant natural killer T cellsLymphocytesProspective study

Identifiers

PMID38025652
PMCPMC10630548
OpenAlexW4387125169

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.