Evidence map›Paper›PMID 38028541›Full record

ArticleFrontiers in molecular biosciences2023

Brain microvascular endothelial cells possess a second cilium that arises from the daughter centriole.

Karthikeyan Thirugnanam, Ankan Gupta, Francisco Nunez, Shubhangi Prabhudesai, Amy Y Pan, Surya M Nauli, Ramani Ramchandran

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Karthikeyan ThirugnanamDepartment of Pediatrics, Division of Neonatology, Developmental Vascular Biology Program, Medical College of Wisconsin, Children's Research Institute (CRI), Milwaukee, WI, United States.
Ankan GuptaDepartment of Pediatrics, Division of Neonatology, Developmental Vascular Biology Program, Medical College of Wisconsin, Children's Research Institute (CRI), Milwaukee, WI, United States.
Francisco NunezDepartment of Pharmaceutical Sciences, Chapman University, Irvine, CA, United States.
Shubhangi PrabhudesaiDepartment of Pediatrics, Division of Neonatology, Developmental Vascular Biology Program, Medical College of Wisconsin, Children's Research Institute (CRI), Milwaukee, WI, United States.
Amy Y PanDepartment of Pediatrics, Division of Quantitative Health Sciences, Medical College of Wisconsin, Children's Research Institute, Milwaukee, WI, United States.
Surya M NauliDepartment of Pharmaceutical Sciences, Chapman University, Irvine, CA, United States.
Ramani RamchandranDepartment of Pediatrics, Division of Neonatology, Developmental Vascular Biology Program, Medical College of Wisconsin, Children's Research Institute (CRI), Milwaukee, WI, United States.
Children's Hospital of Wisconsin · USChapman University · USMedical College of Wisconsin · US

Funding

Cilia as a biomarker of CNS vascular healthR33HL154254 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI NAULI, SURYA, PALECEK, SEAN P · 2022 to 2024
$1.9M
Cilia as a biomarker of CNS vascular healthR61HL154254 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI NAULI, SURYA, PALECEK, SEAN P · 2020 to 2021
$1.3M
Basolateral brain endothelial cilia and its role in promoting vascular stabilityR01HL179583 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Ramani Ramchandran, Lianchun Wang · 2025 to 2026
$1.3M
NHLBI NIH HHS R01 HL179583NHLBI NIH HHS R33 HL154254NHLBI NIH HHS R61 HL154254
6 · The paper itself

Abstract

Primary cilia from the brain microvascular endothelial cells (ECs) are specialized cell-surface organelles involved in mediating sensory perception, cell signaling, and vascular stability. Immunofluorescence (IF) analysis of human primary brain microvascular ECs reveals two cilia per cell. To confirm the

Indexed as

brain endothelial cellcell cycleciliaG0PKD2

Identifiers

PMID38028541
PMCPMC10657992
OpenAlexW4388424744

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.