Evidence map›Paper›PMID 38030384›Full record

ArticleESC heart failure2024

Clinical predictors of right ventricular dysfunction and association with adverse outcomes in peripartum cardiomyopathy.

Tasnim F Imran, Feven Ataklte, Mahnoor Khalid, Diana Lopez, Donya Mohebali, Natalie A Bello, J Michael Gaziano, Luc Djousse, Zolt Arany, Marwa A Sabe and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. 2024 update in heart failure.ESC heart failure · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Tasnim F ImranProvidence VA Medical Center, Warren Alpert Medical School of Brown University, 830 Chalkstone Ave, Providence, RI, 02809, USA.ORCID https://orcid.org/0000-0003-2089-8244
Feven AtaklteProvidence VA Medical Center, Warren Alpert Medical School of Brown University, 830 Chalkstone Ave, Providence, RI, 02809, USA.
Mahnoor KhalidLifespan Cardiovascular Institute, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Diana LopezBrigham and Women's Hospital and the VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA.
Donya MohebaliIntermountain Medical Center, Salt Lake City, UT, USA.
Natalie A BelloSmidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.
J Michael GazianoBrigham and Women's Hospital and the VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA.
Luc DjousseBrigham and Women's Hospital and the VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA.
Zolt AranyCardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Marwa A SabeBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Katharine FrenchLifespan Cardiovascular Institute, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Athena PoppasLifespan Cardiovascular Institute, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Wen-Chih WuProvidence VA Medical Center, Warren Alpert Medical School of Brown University, 830 Chalkstone Ave, Providence, RI, 02809, USA.
Gaurav ChoudharyProvidence VA Medical Center, Warren Alpert Medical School of Brown University, 830 Chalkstone Ave, Providence, RI, 02809, USA.
Brown University · USBrigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USCardiovascular Institute of the South · USCedars-Sinai Medical Center · USIntermountain Medical Center · US

Funding

Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
NIGMS NIH HHS 5P20GM103652-10NIGMS NIH HHS P20 GM103652
6 · The paper itself

Abstract

aimsWe sought to identify factors associated with right ventricular (RV) dysfunction and elevated pulmonary artery systolic pressure (PASP) and association with adverse outcomes in peripartum cardiomyopathy (PPCM). METHODS AND

resultsWe conducted a multi-centre cohort study to identify subjects with PPCM with the following criteria: left ventricular ejection fraction (LVEF) < 40%, development of heart failure within the last month of pregnancy or 5 months of delivery, and no other identifiable cause of heart failure with reduced ejection fraction. Outcomes included a composite of (i) major adverse events (need for extracorporeal membrane oxygenation, ventricular assist device, orthotopic heart transplantation, or death) or (ii) recurrent heart failure hospitalization. RV function was obtained from echocardiogram reports. In total, 229 women (1993-2017) met criteria for PPCM. Mean age was 32.4 ± 6.8 years, 28% were of African descent, 50 (22%) had RV dysfunction, and 38 (17%) had PASP ≥ 30 mmHg. After a median follow-up of 3.4 years (interquartile range 1.0-8.8), 58 (25%) experienced the composite outcome of adverse events. African descent, family history of cardiomyopathy, LVEF, and PASP were significant predictors of RV dysfunction. Using Cox proportional hazards models, we found that women with RV dysfunction were three times more likely to experience the adverse composite outcome: hazard ratio 3.21 (95% confidence interval: 1.11-9.28), P = 0.03, in a multivariable model adjusting for age, race, body mass index, preeclampsia, hypertension, diabetes, kidney disease, and LVEF. Women with PASP ≥ 30 mmHg had a lower probability of survival free from adverse events (log-rank P = 0.04).

conclusionsAfrican descent and family history of cardiomyopathy were significant predictors of RV dysfunction. RV dysfunction and elevated PASP were significantly associated with a composite of major adverse cardiac events. This at-risk group may prompt closer monitoring or early referral for advanced therapies.

Indexed as

CardiomyopathiesHeart FailureVentricular Dysfunction, RightAdultCohort StudiesFemaleHumansPeripartum PeriodPregnancyProspective StudiesStroke VolumeVentricular Function, LeftAdverse outcomesPeripartum cardiomyopathyPregnancy-associated heart failurePulmonary hypertensionRight ventricular dysfunction

Identifiers

PMID38030384
PMCPMC10804155
OpenAlexW4389154150

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.