Evidence map›Paper›PMID 38033201›Full record

ArticleAnalytical chemistry2023

CHRISTMAS: Chiral Pair Isobaric Labeling Strategy for Multiplexed Absolute Quantitation of Enantiomeric Amino Acids.

Zhijun Zhu, Shuling Xu, Zicong Wang, Daniel G Delafield, Michael J Rigby, Gaoyuan Lu, Ting-Jia Gu, Peng-Kai Liu, Min Ma, Luigi Puglielli and 1 more

Abstract read
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Stereoselective Amine-omics Using Heavy Atom Isotope Labeled l- and d-Marfey's Reagents.Journal of the American Society for Mass Spectrometry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhijun ZhuDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0009-0002-9465-498X
Shuling XuSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Zicong WangSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Daniel G DelafieldDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0003-2989-9833
Michael J RigbyDepartment of Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.ORCID 0000-0001-8809-2648
Gaoyuan LuSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Ting-Jia GuSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Peng-Kai LiuBiophysics Program, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Min MaSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Luigi PuglielliDepartment of Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Lingjun LiDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0003-0056-3869

Funding

TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
Mass Spectrometric Studies of Neuropeptides in FeedingR01DK071801 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2006 to 2026
$6.7M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Spastic paraplegia, neurodegeneration and autism: possible role for AT- 1/SLC33A1?R01NS094154 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Luigi Puglielli · 2015 to 2026
$4.3M
Creating a region- specific biomolecular atlas of the brain of Alzheimer’s diseaseR01AG078794 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI, Luigi Puglielli · 2022 to 2026
$3.7M
Di-Leu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer's diseaseRF1AG052324 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2018 to 2018
$2.4M
DiLeu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer’s diseaseR01AG052324 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2023 to 2026
$2.3M
Acquisition of a High-Field Dual Source FTICR-MS for Pharmaceutical ResearchS10RR029531 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2011 to 2011
$2.1M
Acquisition of a Dual-Source, High-Performance, Ion Mobility, Quadrupole Time-of-Flight Mass Spectrometry System for Biomedical Research at UW-MadisonS10OD028473 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2021 to 2021
$1.3M
Acquisition of a High Resolution High Speed MALDI Mass Spectrometer for Biomedical Research at UW-MadisonS10OD025084 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2018 to 2018
$598k
Probing Protein Structural Changes in Alzheimers DiseaseR21AG065728 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2020 to 2020
$420k
NCRR NIH HHS S10 RR029531NIA NIH HHS R01 AG052324NIA NIH HHS R01 AG078794NIA NIH HHS R21 AG065728NIA NIH HHS RF1 AG052324NIDDK NIH HHS R01 DK071801NIGMS NIH HHS P41 GM108538NIGMS NIH HHS T32 GM140935NIH HHS S10 OD025084NIH HHS S10 OD028473NINDS NIH HHS R01 NS094154
6 · The paper itself

Abstract

Amino acids (AAs) in the d-form are involved in multiple pivotal neurological processes, although their l-enantiomers are most commonly found. Mass spectrometry-based analysis of low-abundance d-AAs has been hindered by challenging enantiomeric separation from l-AAs, low sensitivity for detection, and lack of suitable internal standards for accurate quantification. To address these critical gaps,

Indexed as

Amino AcidsProteomicsAminesAnimalsChromatography, LiquidLeucineMiceAminesAmino AcidsLeucine

Identifiers

PMID38033201
PMCPMC10872458

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.