Evidence map›Paper›PMID 38039892›Full record

ArticleComputers in biology and medicine2024

Learning reduced-order models for cardiovascular simulations with graph neural networks.

Luca Pegolotti, Martin R Pfaller, Natalia L Rubio, Ke Ding, Rita Brugarolas Brufau, Eric Darve, Alison L Marsden

Open access · greenAbstract read
In one paragraph

Article in Computers in biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Physics-Informed Emulation of Systemic Circulation for Fast Parameter Estimation and Uncertainty Quantification.International journal for numerical methods in biomedical engineering · 2026
    Article
  7. Full-field surrogate modeling of cardiac electrophysiology encoding geometric variability.Computer methods in applied mechanics and engineering · 2026
    Article
  8. Article
  9. Guidelines for mechanistic modeling and analysis in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Branched Latent Neural Maps.Computer methods in applied mechanics and engineering · 2024
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Luca PegolottiDepartment of Pediatrics, Stanford University, United States of America; Institute for Computational and Mathematical Engineering, Stanford University, United States of America. Electronic address: lpego@stanford.edu.
Martin R PfallerDepartment of Pediatrics, Stanford University, United States of America; Institute for Computational and Mathematical Engineering, Stanford University, United States of America.
Natalia L RubioDepartment of Mechanical Engineering, Stanford University, United States of America.
Ke DingIntel Corporation, United States of America.
Rita Brugarolas BrufauIntel Corporation, United States of America.
Eric DarveInstitute for Computational and Mathematical Engineering, Stanford University, United States of America; Department of Mechanical Engineering, Stanford University, United States of America.
Alison L MarsdenDepartment of Pediatrics, Stanford University, United States of America; Institute for Computational and Mathematical Engineering, Stanford University, United States of America; Department of Mechanical Engineering, Stanford University, United States of America; Department of Bioengineering, Stanford University, United States of America.
Stanford University · USIntel (United States) · US

Funding

SCH: INT: A Virtual Surgery Simulator to Accelerate Medical Training in Cardiovascular Disease R01EB029362 · NIBIB · STANFORD UNIVERSITY · PI MARSDEN, ALISON L · 2019 to 2022
$1.4M
Automated data curation to ensure model credibility in the Vascular Model RepositoryR01LM013120 · NLM · STANFORD UNIVERSITY · PI MARSDEN, ALISON L · 2019 to 2021
$1.0M
Computational Stability Analysis to Predict Heart Failure after Myocardial InfarctionK99HL161313 · NHLBI · STANFORD UNIVERSITY · PI PFALLER, MARTIN R · 2022 to 2023
$324k
NHLBI NIH HHS K99 HL161313NIBIB NIH HHS R01 EB029362NLM NIH HHS R01 LM013120
6 · The paper itself

Abstract

Reduced-order models based on physics are a popular choice in cardiovascular modeling due to their efficiency, but they may experience loss in accuracy when working with anatomies that contain numerous junctions or pathological conditions. We develop one-dimensional reduced-order models that simulate blood flow dynamics using a graph neural network trained on three-dimensional hemodynamic simulation data. Given the initial condition of the system, the network iteratively predicts the pressure and flow rate at the vessel centerline nodes. Our numerical results demonstrate the accuracy and generalizability of our method in physiological geometries comprising a variety of anatomies and boundary conditions. Our findings demonstrate that our approach can achieve errors below 3% for pressure and flow rate, provided there is adequate training data. As a result, our method exhibits superior performance compared to physics-based one-dimensional models while maintaining high efficiency at inference time.

Indexed as

Cardiovascular SystemNeural Networks, ComputerComputer SimulationHemodynamicsModels, CardiovascularCardiovascular modelingGraph neural networksReduced-order models

Identifiers

PMID38039892
PMCPMC10886437
OpenAlexW4388805587

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.