Evidence map›Paper›PMID 38044337›Full record

ArticleArchives of orthopaedic and trauma surgery2024

Application of an in-hospital, surgeon-led anti-osteoporotic medication algorithm in patients with hip fractures improves persistence to medication and can prevent the second fragility fracture.

Ioannis I Daskalakis, Evangelos I Kritsotakis, Apostolos H Karantanas, Georgios M Kontakis, Johannes D Bastian, Theodoros H Tosounidis

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Article in Archives of orthopaedic and trauma surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Introduction of an order set after hip fracture improves osteoporosis medication initiation and persistence: a population-based before-after analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Article
4 · The record

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5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Ioannis I DaskalakisDepartment of Orthopaedic Surgery, University Hospital Heraklion, 71500, Heraklion, Crete, Greece.
Evangelos I KritsotakisLaboratory of Biostatistics, School of Medicine, University of Crete, Heraklion, Greece.
Apostolos H KarantanasDepartment of Radiology, Medical School, University of Crete, 71110, Heraklion, Greece.
Georgios M KontakisDepartment of Orthopaedic Surgery, University Hospital Heraklion, 71500, Heraklion, Crete, Greece.
Johannes D BastianDepartment of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Theodoros H TosounidisDepartment of Orthopaedic Surgery, University Hospital Heraklion, 71500, Heraklion, Crete, Greece. ttosounidis@yahoo.com.
University of Crete · GRFoundation for Research and Technology Hellas · GRUniversity Hospital of Heraklion · GRUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSecondary fracture prevention is an essential part of hip fracture treatment. Despite this, many patients are discharged without the appropriate anti-osteoporotic medication. The aim of this study is to report the outcomes of the application of an in-hospital, surgeon-led anti-osteoporotic medication algorithm to patients with hip fractures. MATERIALS AND

methodsThis prospective cohort study followed patients with hip fractures who were treated at a tertiary referral hospital between 2020 and 2022. At discharge, anti-osteoporotic medication according to the Arbeitsgemeinschaft für Osteosynthesefragen (AO) Foundation algorithm was prescribed to all patients. Multivariate Cox regression analysis was used to investigate the risks of non-persistence to medication and of secondary fracture.

resultsTwo hundred thirteen consecutive patients were prospectively followed. Mean follow-up was 17.2 ± 7.1 months. Persistence to medication at 2 years was 58% (95%CI 51-65%). A secondary osteoporotic fracture occurred in 1/126 (0.8%) persistent patients and 9/87 (11.4%) non-persistent patients. Multivariable Cox regression analysis confirmed that persistence to medication was significantly associated with a lower risk of secondary fracture (cause-specific hazard ratio [csHR] 0.05; 95%CI 0.01-0.45; p = 0.007).

conclusionThe application of the surgeon-led AO Foundation algorithm enables the in-hospital initiation of anti-osteoporotic treatment, leading to better persistence to medication and decreased incidence of secondary osteoporotic fractures.

Indexed as

Bone Density Conservation AgentsHip FracturesOsteoporosisOsteoporotic FracturesSurgeonsHospitalsHumansProspective StudiesBone Density Conservation AgentsAntiosteoporotic medicationFragility fractureHip fractureOsteoporosisSecondary fractureSecondary fracture prevention

Identifiers

PMID38044337
OpenAlexW4389282120

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.