Evidence map›Paper›PMID 38045296›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Genetic association study of Preterm birth and Gestational age in a population-based case-control study in Peru: Genetics of PTB and GA in pregnant women in Peru.

Diana L Juvinao-Quintero, Sixto E Sanchez, Tsegaselassie Workalemahu, Nelida Pinto, Liming Liang, Michelle A Williams, Bizu Gelaye

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Diana L Juvinao-QuinteroDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-9341-918X
Sixto E SanchezFacultad de Medicina Humana, Instituto de Investigación, Universidad de San Martin de Porres, Lima, Peru.
Tsegaselassie WorkalemahuDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, UT, USA.
Nelida PintoAsociación Civil PROESA, Lima, Peru.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-8261-3174
Michelle A WilliamsDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Bizu GelayeDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-7934-548X
Harvard University · USAsociación Civil Impacta Salud y Educación · PEUniversidad de San Martín de Porres · PEUniversity of Utah · US

Funding

Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic PlacentalR01HD059827 · NICHD · SWEDISH MEDICAL CENTER, FIRST HILL · PI ANANTH, CANDE V., WILLIAMS, MICHELLE A. · 2010 to 2014
$2.7M
The Role of Hypothalamic Pituitary - Adrenal Axis Dysregulation in Preterm BirthR21HD102822 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI GELAYE, BIZU · 2020 to 2021
$447k
NICHD NIH HHS R01 HD059827NICHD NIH HHS R21 HD102822
6 · The paper itself

Abstract

Preterm birth (PTB) is an adverse pregnancy outcome affecting ~15 million pregnancies worldwide. Genetic studies have identified several candidate loci for PTB, but results remain inconclusive and limited to European populations. Thus, we conducted a genome-wide association study (GWAS) of PTB and gestational age at delivery (GA) among 2,212 Peruvian women. PTB cases delivered ≥ 20 weeks' but < 37 weeks' gestation, while controls delivered at term (≥ 37 weeks but < 42 weeks). After imputation (TOPMED) and quality control, we assessed the association of ~6 million SNPs with PTB and GA using multivariable regression models adjusted for maternal age and the first two genetic principal components.

Indexed as

genetic risk scoregestational age at deliveryGWASmaternal genotypepregnancypreterm birth

Identifiers

PMID38045296
PMCPMC10690348
OpenAlexW4388923505

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.