Evidence map›Paper›PMID 38045729›Full record

ArticleFrontiers in cellular neuroscience2023

S-SCAM is essential for synapse formation.

Nina Wittenmayer, Andonia Petkova-Tuffy, Maximilian Borgmeyer, Chungku Lee, Jürgen Becker, Andreas Böning, Sebastian Kügler, JeongSeop Rhee, Julio S Viotti, Thomas Dresbach

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nina WittenmayerInstitute of Anatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany.
Andonia Petkova-TuffyInstitute of Anatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany.
Maximilian BorgmeyerInstitute for Translational Medicine, MSH Medical School Hamburg, Hamburg, Germany.
Chungku LeeDepartment of Molecular Neurobiology, Synaptic Physiology Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Jürgen BeckerInstitute of Anatomy and Cell Biology, University Medical Center Göttingen, Göttingen, Germany.
Andreas BöningInstitute of Anatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany.
Sebastian KüglerDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
JeongSeop RheeDepartment of Molecular Neurobiology, Synaptic Physiology Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Julio S Viotti *Institute of Anatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany.
Thomas Dresbach *Institute of Anatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synapse formation is critical for the wiring of neural circuits in the developing brain. The synaptic scaffolding protein S-SCAM/MAGI-2 has important roles in the assembly of signaling complexes at post-synaptic densities. However, the role of S-SCAM in establishing the entire synapse is not known. Here, we report significant effects of RNAi-induced S-SCAM knockdown on the number of synapses in early stages of network development

Indexed as

neuronal morphologyscaffolding proteinspinesynapse formationsynaptic transmission

Identifiers

PMID38045729
PMCPMC10690602

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.