Evidence map›Paper›PMID 38050135›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

A Frameshift Variant of GluN2A Identified in an Epilepsy Patient Results in NMDA Receptor Mistargeting.

M M Vieira, S Peng, S Won, E Hong, S K Inati, A Thurm, A H Thiam, S Kim, S J Myers, J D Badger and 3 more

Open access · greenAbstract readCase Reports
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. GluN2A: A Promising Target for Developing Novel Antidepressants.The international journal of neuropsychopharmacology · 2024
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

M M VieiraReceptor Biology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda 20892, Maryland.ORCID 0000-0001-7332-6181
S PengSynapse and Neural Circuit Research Section, NINDS, NIH, Bethesda 20892, Maryland.
S WonReceptor Biology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda 20892, Maryland.ORCID 0000-0001-7417-4917
E HongReceptor Biology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda 20892, Maryland.
S K InatiNeurophysiology of Epilepsy Unit, NINDS, NIH, Bethesda 20892, Maryland.
A ThurmNational Institute of Mental Health, National Institutes of Health, Bethesda 20892, Maryland.
A H ThiamOffice of the Clinical Director, NINDS, NIH, Bethesda 20892, Maryland.
S KimDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta 30322, Georgia.
S J MyersDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta 30322, Georgia.
J D BadgerReceptor Biology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda 20892, Maryland.
S F TraynelisDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta 30322, Georgia.ORCID 0000-0002-3750-9615
W LuSynapse and Neural Circuit Research Section, NINDS, NIH, Bethesda 20892, Maryland.ORCID 0000-0001-6668-8432
K W RocheReceptor Biology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda 20892, Maryland rochek@ninds.nih.gov.
National Institutes of Health · USEmory University · USOffice of the Director · US

Funding

Subunit-Specific Regulation Of Glutamate ReceptorsZIANS002994 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ROCHE, KATHERINE · 2009 to 2025
$30.0M
The regulation of synaptic transmission and neural circuit functionZIANS003136 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LU, WEI · 2012 to 2025
$27.0M
Neurodevelopmental and Behavioral Phenotyping ZICMH002961 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI THURM, AUDREY · 2017 to 2025
$12.6M
Glutamate receptors and human neurological diseaseR35NS111619 · NINDS · EMORY UNIVERSITY · PI Stephen F Traynelis · 2019 to 2026
$6.6M
Use of Bioinformatics and Genetics to Identify a New Class of Drugs for Neurological DiseaseR21AG072142 · NIA · EMORY UNIVERSITY · PI MYERS, SCOTT JAMES · 2021 to 2021
$425k
NIA NIH HHS R21 AG072142NINDS NIH HHS R35 NS111619
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Autism Spectrum DisorderEpilepsyAnimalsHumansMaleNeuronsRatsReceptors, N-Methyl-D-AspartateSignal TransductionSynapsesReceptors, N-Methyl-D-AspartateepilepsyNMDARspostsynaptic densityrecyclingScribble1

Identifiers

PMID38050135
PMCPMC10860613
OpenAlexW4389161246

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.