ArticleNature communications2023
Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Retinal and Choroidal Metrics Are Dynamic Markers of the Maternal Vascular Response to Pregnancy.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Retinal Structural and Microvascular Findings on OCT and OCTA in Hemodialysis and Kidney Transplant Recipients and Their Association with Mineral Metabolism Parameters.Medical sciences (Basel, Switzerland) · 2026Article
- Diabetic Retinopathy Severity and Heart Failure Outcomes in Type 2 Diabetes Mellitus.Journal of diabetes · 2026Article
- Plasma proteomic signatures of early retinal neurodegeneration in diabetes: A multi-cohort study.PLoS medicine · 2026Observational
- Multi-omic analysis of deep learning-derived phenotypes links ophthalmic imaging to cardiovascular and neurological traits.Nature cardiovascular research · 2026Article
- Explainable retinal deep learning for cardiovascular risk stratification: a multiple modality analysis framework with vascular-centric interpretability and robustness.BMC medical informatics and decision making · 2026Article
- Non-invasive biomarkers for diabetic complications: insights from corneal and retinal imaging.Acta diabetologica · 2026Article
- Optical Coherence Tomography and Optical Coherence Tomography-Angiography Chronic Changes in End-Stage Renal Disease: A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Artificial intelligence-based quantification of retinal microvascular biomarkers from fundus photography of chronic kidney disease: a case-control study.Frontiers in medicine · 2026Article
- Choroidal microcirculation in pediatric craniopharyngioma: postoperative alterations in choroidal thickness.Frontiers in pediatrics · 2026Article
- Nationwide Analysis of Progressive Kidney Function Decline and Diabetic Macular Edema in Type 2 Diabetes.Ophthalmology science · 2026Article
- Ocular biomarkers in diabetes mellitus with diabetic kidney disease: A minireview.World journal of nephrology · 2025Review
- Early Renal Dysfunction and Reduced Retinal Vascular Density Assessed by Angio-OCT in Hypertensive Patients.Biomedicines · 2025Article
- Latent retinal structural patterns with aging.NPJ digital medicine · 2025Article
- Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop.Nature reviews. Cardiology · 2025Review
- Ocular Biometry Profile and Its Associations with Systemic and Demographic Factors in Thai Cataract Patients.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Oculomic stratification of COVID-19 patients' intensive therapy unit admission status and mortality by retinal morphological findings.Scientific reports · 2024Article
- Looking into the Eyes to See the Heart of Chronic Kidney Disease Patients.Life (Basel, Switzerland) · 2024Article
- Quantitative assessment of retinal vasculature changes in systemic lupus erythematosus using wide-field OCTA and the correlation with disease activity.Frontiers in immunology · 2024Observational
- OCT Angiography-Derived Retinal Capillary Perfusion Measures in the Framingham Heart Study.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response, and predict outcomes. Here, we investigate the potential of retinal optical coherence tomography (OCT) to achieve these ends in a series of prospective studies of patients with pre-dialysis CKD (including those with a kidney transplant), patients with kidney failure undergoing kidney transplantation, living kidney donors, and healthy volunteers. Compared to health, we observe similar retinal thinning and reduced macular volume in patients with CKD and in those with a kidney transplant. However, the choroidal thinning observed in CKD is not seen in patients with a kidney transplant whose choroids resemble those of healthy volunteers. In CKD, the degree of choroidal thinning relates to falling eGFR and extent of kidney scarring. Following kidney transplantation, choroidal thickness increases rapidly (~10%) and is maintained over 1-year, whereas gradual choroidal thinning is seen during the 12 months following kidney donation. In patients with CKD, retinal and choroidal thickness independently associate with eGFR decline over 2 years. These observations highlight the potential for retinal OCT to act as a non-invasive monitoring and prognostic biomarker of kidney injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.