PCSK9 inhibitors × lipids

SynthesisPloS one2023

Proprotein convertase subtilisn/kexin type 9 inhibitors and small interfering RNA therapy for cardiovascular risk reduction: A systematic review and meta-analysis.

Tasnim F Imran et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 87,669 people · 2023

Randomised comparison

Lowered lipids

−61.1percentage points−64.8 to −57.4

As reported

difference −61.09 %, 95% CI −64.8 to −57.4

Randomised comparison

Lowered lipids

−46.4percentage points−51.8 to −41.1

As reported

difference −46.35 %, 95% CI −51.8 to −41.1

Randomised comparison

Lowered lipids

−54.8percentage points−59.0 to −50.6

As reported

difference −54.83 %, 95% CI −59.0 to −50.6

Randomised comparison

Lowered lipids

−43.1percentage points−52.4 to −33.8

As reported

difference −43.11 %, 95% CI −52.4 to −33.8

+1 more in the walkthrough ↓

Five numbers in the abstract

the abstract, start to end

(IQR 12-52), Evolocumab reduced LDL-c by -61.09% (95% CI: -64.81, -57.38, p<0.01) and Alirocumab reduced LDL-c by -46.35% (95% CI: -51.75, -41.13,

Inclisiran 284mg reduced LDL-c by -54.83% (95% CI: -59.04, -50.62, p = 0.05) and Inclisiran 300mg reduced LDL-c by -43.11% (95% CI: -52.42, -33.80, p =

risk of myocardial infarction (MI), OR 0.72 (95% CI: 0.64, 0.81, p<0.01),

← favours treatmentfavours comparator →
could be chance
Lipids
−61.09−64.8 to −57.4
Lipids
−46.35−51.8 to −41.1
Lipids
−54.83−59.0 to −50.6
Lipids
−43.11−52.4 to −33.8
Cardiovascular events
OR 0.720.64–0.81
PCSK9 inhibitorsLipidsCardiovascular events

PCSK9 inhibitors × lipidshelps?settled

unlikelylikely
0.93not counted
← favours treatmentfavours comparator →
more certainless certain
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19 papers cite it

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Full record →Abstract, authors, funding and every citing paper · PMID 38055686