Evidence map›Paper›PMID 38060559›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Integrin α

Heng Zhang, Zhengli Wang, Huong T T Nguyen, Abigail J Watson, Qifang Lao, An Li, Jieqing Zhu

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. ACE2: Friend or Foe in Post-COVID-19 Neurodegeneration?International journal of molecular sciences · 2025
    Review
  6. Review
  7. Article
  8. Molecular mechanisms of SARS-CoV-2 entry: implications for biomedical strategies.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Sound healing and beyond.Nature biotechnology · 2025
    Article
  13. Review
  14. Facilitating and restraining virus infection using cell-attachable soluble viral receptors.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Heng ZhangThrombosis and Hemostasis Program, Versiti Blood Research Institute, Milwaukee, WI 53226.ORCID 0000-0002-6580-2464
Zhengli Wang *Thrombosis and Hemostasis Program, Versiti Blood Research Institute, Milwaukee, WI 53226.
Huong T T Nguyen *Thrombosis and Hemostasis Program, Versiti Blood Research Institute, Milwaukee, WI 53226.
Abigail J WatsonThrombosis and Hemostasis Program, Versiti Blood Research Institute, Milwaukee, WI 53226.ORCID 0000-0002-4663-9091
Qifang LaoThrombosis and Hemostasis Program, Versiti Blood Research Institute, Milwaukee, WI 53226.
An LiThrombosis and Hemostasis Program, Versiti Blood Research Institute, Milwaukee, WI 53226.
Jieqing ZhuThrombosis and Hemostasis Program, Versiti Blood Research Institute, Milwaukee, WI 53226.ORCID 0000-0003-4508-4263
Versiti Blood Center of Wisconsin · USMedical College of Wisconsin · US

Funding

Structural Transition of Cellular Integrins and Applications ThereofR01HL131836 · NHLBI · VERSITI WISCONSIN, INC. · PI Jieqing Zhu · 2016 to 2026
$5.5M
Non-conventional signaling by α5 integrin in blood and endothelial cellsR01HL175474 · NHLBI · VERSITI WISCONSIN, INC. · PI Jieqing Zhu · 2024 to 2026
$2.2M
Structural Mechanisms Underlying the Activity Regulation of the Receptor-like Protein Tyrosine Phosphatase, CD148/PTPRJR01GM137143 · NIGMS · VERSITI WISCONSIN, INC. · PI ZHU, JIEQING · 2020 to 2023
$1.4M
NHLBI NIH HHS R01 HL131836NHLBI NIH HHS R01 HL175474NIGMS NIH HHS R01 GM137143
6 · The paper itself

Abstract

The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infects host cells by engaging its spike (S) protein with human ACE2 receptor. Recent studies suggest the involvement of integrins in SARS-CoV-2 infection through interaction with the S protein, but the underlying mechanism is not well understood. This study investigated the role of integrin α

Indexed as

COVID-19Integrin alpha5beta1Angiotensin-Converting Enzyme 2Cell FusionEndothelial CellsHumansInflammationIntegrinsOligopeptidesSARS-CoV-2Spike Glycoprotein, CoronavirusAngiotensin-Converting Enzyme 2arginyl-glycyl-aspartic acidIntegrin alpha5beta1IntegrinsOligopeptidesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2cell fusioninflammationintegrinSARS-CoV-2

Identifiers

PMID38060559
PMCPMC10723138
OpenAlexW4389429808

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.