Evidence map›Paper›PMID 38064009›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2024

Anxiety and dysautonomia symptoms in patients with a Na

Rita de Cássia Collaço, Maxime Lammens, Carley Blevins, Kristen Rodgers, Andrei Gurau, Suguru Yamauchi, Christine Kim, Jeannine Forrester, Edward Liu, Jinny Ha and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. A neurocutaneous NaScience advances · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Rita de Cássia Collaço *Molecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, University of Ghent, Ghent, Belgium.
Maxime Lammens *Molecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, University of Ghent, Ghent, Belgium.
Carley Blevins *Department of Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Kristen RodgersDepartment of Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Andrei GurauDepartment of Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Suguru YamauchiDepartment of Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Christine KimDepartment of Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Jeannine ForresterDepartment of Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Edward LiuDepartment of Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Jinny HaDepartment of Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Yuping MeiDepartment of Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Corrine BoehmMcKusick-Nathans Department of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Elizabeth WohlerMcKusick-Nathans Department of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Nara SobreiraMcKusick-Nathans Department of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Peter C RoweDepartment of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
David ValleMcKusick-Nathans Department of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Malcolm V BrockDepartment of Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. mabrock@jhmi.edu.
Frank BosmansMolecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, University of Ghent, Ghent, Belgium. frank.bosmans@ugent.be.ORCID http://orcid.org/0000-0002-0451-6050
Johns Hopkins University · USGhent University · BE

Funding

Baylor-Johns Hopkins Center for Mendelian GeneticsUM1HG006542 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2016 to 2020
$14.5M
Clinical and Laboratory Research Training for Surgical OncologistsT32CA126607 · NCI · JOHNS HOPKINS UNIVERSITY · PI CAMERON, ANDREW M. · 2008 to 2024
$6.0M
Sodium channel mutations as a possible cause for primary dysautonomiaR01NS126398 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MALCOLM V BROCK · 2023 to 2026
$1.9M
NCI NIH HHS T32 CA126607NHGRI NIH HHS UM1 HG006542NIH HHS 3UM1HG006542NIH HHS T32CA126607NINDS NIH HHS R01 NS126398NINR NIH HHS R01NS126398
6 · The paper itself

Abstract

purposeGuanfacine is an α

methodsWe used whole-exome sequencing to identify mutations in patients with shared generalized anxiety and dysautonomia symptoms. Guanfacine-induced changes in the function of voltage-gated Na

resultsWhole-exome sequencing uncovered the p.I739V mutation in SCN9A in the proband of two nonrelated families. Moreover, guanfacine inhibited ionic currents evoked by wild-type and mutant Na

conclusionOur study provides further evidence for a possible pathophysiological role of Na

Indexed as

Autonomic Nervous System DiseasesGuanfacineAdrenergic alpha-AgonistsAnxietyHumansMutationNAV1.7 Voltage-Gated Sodium ChannelAdrenergic alpha-AgonistsGuanfacineNAV1.7 Voltage-Gated Sodium ChannelSCN9A protein, humanAnxietyDysautonomiaGuanfacineNaV1.7Voltage-gated sodium channel

Identifiers

PMID38064009
PMCPMC11805752
OpenAlexW4389487270

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.