Evidence map›Paper›PMID 38067271›Full record

ArticleCancers2023

TIL-Derived CAR T Cells Improve Immune Cell Infiltration and Survival in the Treatment of CD19-Humanized Mouse Colorectal Cancer.

Can Zhu, Yuanyuan Zhao, Jiaheng He, Huan Zhao, Li Ni, Xinyi Cheng, Yida Chen, Liqian Mu, Xiaojun Zhou, Qin Shi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Can ZhuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College, Soochow University, 899 Pinghai Road, Suzhou 215031, China.
Yuanyuan ZhaoNational Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou 215031, China.
Jiaheng HeDepartment of Orthopaedics, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, No. 1399, Market West Road, Shengze Town, Suzhou 215000, China.
Huan ZhaoDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College, Soochow University, 899 Pinghai Road, Suzhou 215031, China.
Li NiDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College, Soochow University, 899 Pinghai Road, Suzhou 215031, China.
Xinyi ChengDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College, Soochow University, 899 Pinghai Road, Suzhou 215031, China.
Yida ChenDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College, Soochow University, 899 Pinghai Road, Suzhou 215031, China.
Liqian MuDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou Medical College, Soochow University, 899 Pinghai Road, Suzhou 215031, China.
Xiaojun ZhouDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou Medical College, Soochow University, 899 Pinghai Road, Suzhou 215031, China.
Qin ShiDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College, Soochow University, 899 Pinghai Road, Suzhou 215031, China.
Jie SunDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College, Soochow University, 899 Pinghai Road, Suzhou 215031, China.
Soochow University · CNFirst Affiliated Hospital of Soochow University · CNJiangsu Shengze Hospital · CN

Funding

This work was supported by National Natural Science Foundation of China 82172485, 82172487, 81972059
6 · The paper itself

Abstract

Chimeric antigen receptor-engineered T cells (CAR Ts) targeting CD19 have shown unprecedented prognosis in treating hematological cancers. However, the lack of a tumor-specific antigen as the target and an inhospitable tumor environment limit the clinical application of CAR T in solid tumors. Tumor-infiltrating T lymphocytes (TIL) exhibit diverse T cell receptor clonality and superior tumor-homing abilities. Therefore, in our study, human CD19-target TIL CAR-Ts armed with CD3ζ and 4-1BB signaling domains were constructed. Mouse colorectal cancer CT26 cells expressing human CD19 (hCD19

Indexed as

CAR Tcolorectal cancerimmunotherapytumor-infiltrating T cell

Identifiers

PMID38067271
PMCPMC10705672
OpenAlexW4388971608

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.