Evidence map›Paper›PMID 38069412›Full record

ArticleInternational journal of molecular sciences2023

Laser-Synthesized Elemental Boron Nanoparticles for Efficient Boron Neutron Capture Therapy.

Irina N Zavestovskaya, Anna I Kasatova, Dmitry A Kasatov, Julia S Babkova, Ivan V Zelepukin, Ksenya S Kuzmina, Gleb V Tikhonowski, Andrei I Pastukhov, Kuder O Aiyyzhy, Ekaterina V Barmina and 9 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Irina N ZavestovskayaP. N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow 119991, Russia.
Anna I KasatovaLaboratory of BNCT, Budker Institute of Nuclear Physics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Dmitry A KasatovLaboratory of BNCT, Budker Institute of Nuclear Physics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Julia S BabkovaInstitute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University MEPhI, Moscow 115409, Russia.
Ivan V ZelepukinInstitute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University MEPhI, Moscow 115409, Russia.ORCID 0000-0003-0209-2116
Ksenya S KuzminaLaboratory of BNCT, Budker Institute of Nuclear Physics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Gleb V TikhonowskiInstitute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University MEPhI, Moscow 115409, Russia.
Andrei I PastukhovLP3, Aix-Marseille University, CNRS, 13288 Marseille, France.
Kuder O AiyyzhyA. M. Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia.
Ekaterina V BarminaA. M. Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia.
Anton A PopovInstitute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University MEPhI, Moscow 115409, Russia.
Ivan A RazumovInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.ORCID 0000-0002-6756-1457
Evgenii L ZavjalovInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Maria S GrigoryevaP. N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow 119991, Russia.
Sergey M KlimentovInstitute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University MEPhI, Moscow 115409, Russia.
Vladimir A RyabovP. N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow 119991, Russia.
Sergey M DeyevInstitute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University MEPhI, Moscow 115409, Russia.ORCID 0000-0002-3952-0631
Sergey Yu TaskaevLaboratory of BNCT, Budker Institute of Nuclear Physics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Andrei V KabashinLP3, Aix-Marseille University, CNRS, 13288 Marseille, France.ORCID 0000-0003-1549-7198
Institute of Engineering Physics · RUBudker Institute of Nuclear Physics · RUP.N. Lebedev Physical Institute of the Russian Academy of Sciences · RUCentre National de la Recherche Scientifique · FRInstitute of Cytology and Genetics · RUProkhorov General Physics Institute · RUSechenov University · RU

Funding

Neutron irradiation was supported by the Russian Science Foundation, project No. 19-72-30005. No. 19-72-30005This research was funded by the Ministry of Science and Higher Education of Russian Federation within the Agreement no. 075-15-2021-1347. no. 075-15-2021-1347
6 · The paper itself

Abstract

Boron neutron capture therapy (BNCT) is one of the most appealing radiotherapy modalities, whose localization can be further improved by the employment of boron-containing nanoformulations, but the fabrication of biologically friendly, water-dispersible nanoparticles (NPs) with high boron content and favorable physicochemical characteristics still presents a great challenge. Here, we explore the use of elemental boron (B) NPs (BNPs) fabricated using the methods of pulsed laser ablation in liquids as sensitizers of BNCT. Depending on the conditions of laser-ablative synthesis, the used NPs were amorphous (a-BNPs) or partially crystallized (pc-BNPs) with a mean size of 20 nm or 50 nm, respectively. Both types of BNPs were functionalized with polyethylene glycol polymer to improve colloidal stability and biocompatibility. The NPs did not initiate any toxicity effects up to concentrations of 500 µg/mL, based on the results of MTT and clonogenic assay tests. The cells with BNPs incubated at a

Indexed as

Boron Neutron Capture TherapyNanoparticlesAnimalsBoronLasersMiceMice, SCIDTissue DistributionBoronboron nanoparticlesboron neutron capture therapycancer treatmentlaser-ablative synthesis

Identifiers

PMID38069412
PMCPMC10707216
OpenAlexW4389300701

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.