Evidence map›Paper›PMID 38071313›Full record

ArticleScientific data2023

The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds.

Pavel Prado, Vicente Medel, Raul Gonzalez-Gomez, Agustín Sainz-Ballesteros, Victor Vidal, Hernando Santamaría-García, Sebastian Moguilner, Jhony Mejia, Andrea Slachevsky, Maria Isabel Behrens and 13 more

Erratum issuedAbstract readDataset
In one paragraph

Article in Scientific data, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Linking the exposome to the brain-behaviour phenotype.Nature reviews. Neuroscience · 2026
    Review
  5. Article
  6. Empirical validation of race-neutral normative brain morphometry models across ethnoracially diverse populations.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Domain-adapted language model using reinforcement learning for various dementias.medRxiv : the preprint server for health sciences · 2026
    Article
  9. Article
  10. The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
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  19. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Pavel Prado *Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.
Vicente Medel *Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.
Raul Gonzalez-GomezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.ORCID 0000-0003-2341-011X
Agustín Sainz-BallesterosLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.
Victor VidalLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.
Hernando Santamaría-GarcíaPhD Neuroscience Program, Physiology and Psychiatry Departments, Pontificia Universidad Javeriana, Bogotá, Colombia.
Sebastian MoguilnerLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.
Jhony MejiaLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.ORCID 0000-0002-0313-6902
Andrea SlachevskyNeuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Department - Institute of Biomedical Sciences (ICBM), Neurocience and East Neuroscience Departments, Faculty of Medicine, University of Chile, Santiago de Chile, Chile.
Maria Isabel BehrensCentro de Investigación Clínica Avanzada (CICA), Facultad de Medicina-Hospital Clínico, Universidad de Chile, Independencia, Santiago, 8380453, Chile.
David AguillonGrupo de Neurociencias de Antioquia de la Universidad de Antioquia, Medellín, Colombia.ORCID 0000-0003-2283-536X
Francisco LoperaGrupo de Neurociencias de Antioquia de la Universidad de Antioquia, Medellín, Colombia.
Mario A ParraSchool of Psychological Sciences and Health, University of Strathclyde, Glasgow, United Kingdom.
Diana MatallanaPhD Neuroscience Program, Physiology and Psychiatry Departments, Pontificia Universidad Javeriana, Bogotá, Colombia.
Marcelo Adrián MaitoLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.
Adolfo M GarciaGlobal Brain Health Institute, University of California San Francisco, San Francisco, USA.
Nilton CustodioUnit Cognitive Impairment and Dementia Prevention, Peruvian Institute of Neurosciences, Lima, Peru.
Alberto Ávila FunesGeriatrics Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Stefanie Piña-EscuderoGlobal Brain Health Institute, University of California San Francisco, San Francisco, USA.
Agustina BirbaLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.
Sol FittipaldiLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.ORCID 0000-0001-7704-3349
Agustina LegazLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.
Agustín IbañezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile. agustin.ibanez@gbhi.org.ORCID 0000-0001-6758-5101

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
NIA NIH HHS P01 AG019724NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG075775
6 · The paper itself

Abstract

The Latin American Brain Health Institute (BrainLat) has released a unique multimodal neuroimaging dataset of 780 participants from Latin American. The dataset includes 530 patients with neurodegenerative diseases such as Alzheimer's disease (AD), behavioral variant frontotemporal dementia (bvFTD), multiple sclerosis (MS), Parkinson's disease (PD), and 250 healthy controls (HCs). This dataset (62.7 ± 9.5 years, age range 21-89 years) was collected through a multicentric effort across five Latin American countries to address the need for affordable, scalable, and available biomarkers in regions with larger inequities. The BrainLat is the first regional collection of clinical and cognitive assessments, anatomical magnetic resonance imaging (MRI), resting-state functional MRI (fMRI), diffusion-weighted MRI (DWI), and high density resting-state electroencephalography (EEG) in dementia patients. In addition, it includes demographic information about harmonized recruitment and assessment protocols. The dataset is publicly available to encourage further research and development of tools and health applications for neurodegeneration based on multimodal neuroimaging, promoting the assessment of regional variability and inclusion of underrepresented participants in research.

Indexed as

Alzheimer DiseaseBrainAdultAgedAged, 80 and overDiffusion Magnetic Resonance ImagingHumansMagnetic Resonance ImagingMiddle AgedNeuroimagingYoung Adult

Identifiers

PMID38071313
PMCPMC10710425

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.