Evidence map›Paper›PMID 38073101›Full record

Observational studyCurrent vascular pharmacology2024

QTc Prolongation to Predict Mortality in Patients Admitted with COVID-19 Infection: An Observational Study.

Andrea Sartorio, Giulia Burrei, Luca Cristin, Mirko Zoncapè, Michele Carlin, Enrico Tadiello, Pietro Minuz, Andrea Dalbeni, Simone Romano

Abstract readObservational Study
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In one paragraph

Observational study in Current vascular pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Andrea SartorioDivision of Internal Medicine C, Department of Medicine, University of Verona, Italy.
Giulia BurreiDivision of Internal Medicine C, Department of Medicine, University of Verona, Italy.
Luca CristinDivision of Internal Medicine C, Department of Medicine, University of Verona, Italy.
Mirko ZoncapèDivision of Internal Medicine C, Department of Medicine, University of Verona, Italy.
Michele CarlinDivision of Internal Medicine C, Department of Medicine, University of Verona, Italy.
Enrico TadielloDivision of Internal Medicine C, Department of Medicine, University of Verona, Italy.
Pietro MinuzDivision of Internal Medicine C, Department of Medicine, University of Verona, Italy.
Andrea DalbeniDivision of Internal Medicine C, Department of Medicine, University of Verona, Italy.
Simone RomanoDivision of Internal Medicine C, Department of Medicine, University of Verona, Italy.
University of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes Coronavirus disease 2019 (COVID-19), characterized by pulmonary infection ranging from asymptomatic forms to respiratory insufficiency and death. Evidence of cardiac involvement in COVID-19 is increasing, and systemic inflammation or direct heart damage by SARS-CoV-2 can prolong the corrected QT interval (QTc).

methodsIn this observational study, a total of 333 consecutive patients admitted to the Covid Center of Verona University Hospital from November 2020 to April 2021 were included. Patients with bundle branch block, pacemaker-controlled heart rhythm and heart rate >120 beats/min were excluded. A complete electrocardiogram (ECG) was performed at admission, and QTc values of ≥440 ms for males and ≥460 ms for females were considered prolonged.

resultsOverall, 153 patients had prolonged QTc (45.5%). In multivariate logistic regression analysis, male sex (odds ratio (OR)=6.612, p=0.046), troponin (OR=1.04, p=0.015) and lymphocyte count (OR=3.047, p=0.019) were independently associated with QTc prolongation. Multivariate logistic regression showed that QTc was independently associated with mortality (OR=4.598, p=0.036). Age, sex, the ratio between the partial pressure of oxygen (PaO2) and the fraction of inspired oxygen (FiO2) (P/F), and fibrosis-4 index for liver fibrosis (FIB-4) were also independently associated with mortality.

conclusionQTc interval prolongation appears to be a frequent finding in patients with COVID-19. Moreover, prolonged QTc may be predictive of more severe forms of COVID-19 and worse outcome.

Indexed as

COVID-19ElectrocardiographyLong QT SyndromeAgedAged, 80 and overFemaleHeart RateHumansItalyMaleMiddle AgedPatient AdmissionPredictive Value of TestsPrognosisRisk AssessmentRisk FactorsCOVID-19COVID-19 drugsmortalitypneumoniaQTc prolongationSARS-CoV-2.

Identifiers

PMID38073101
OpenAlexW4389569679

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.