Evidence map›Paper›PMID 38076169›Full record

ArticleHeliyon2023

Knockdown of FOXRED2 restrains proliferation, invasion and migration of human melanoma cells.

Mujin Li, Si Qin, Zhijun Xu, Yingjun Feng, Sihui Li, Xianwen Li, Zhenyu Lu, Shuting Huang, Siman Shi, Yixue Duan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Mujin LiDepartment of Dermatology, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China.
Si QinDepartment of Dermatology, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China.
Zhijun XuShenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei, 516621, China.
Yingjun FengDepartment of Dermatology, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China.
Sihui LiDepartment of Dermatology, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China.
Xianwen LiDepartment of Dermatology, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China.
Zhenyu LuDepartment of Dermatology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510799, China.
Shuting HuangDepartment of Dermatology, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China.
Siman ShiDepartment of Dermatology, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China.
Yixue DuanDepartment of Dermatology, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China.
Ju WenDepartment of Dermatology, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China.
Guangdong Provincial People's Hospital · CNSun Yat-sen University · CNGuangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This experiment investigated the role of the FAD-dependent oxidoreductase domain-containing 2 (FOXRED2) in the development of cutaneous malignant melanoma. Methods: We explored the expression and prognostic effects of FOXRED2 in cutaneous malignant melanoma by performing bioinformatics analyses and immunohistochemical staining experiments and verified the biological influence of FOXRED2 on human melanoma cells using in vitro experiments. Results: FOXRED2 expression was significantly higher in cutaneous malignant melanoma compared to normal skin and nevus tissues and closely associated with prognosis. The expression levels of FOXRED2 mRNA and protein were significantly upregulated in human melanoma cell lines, and knocking down FOXRED2 expression inhibits proliferation, invasion, and migration, promotes apoptosis, and alters tumor cell biology in A2058 and A375 cells. Conclusion: FOXRED2 may play a crucial role in the development and progression of cutaneous malignant melanoma.

Indexed as

BioinformaticsCutaneous malignant melanomaFOXRED2 proteinHuman melanoma cell linesTumor biology

Identifiers

PMID38076169
PMCPMC10703634
OpenAlexW4389195701

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.