ArticleBiological psychiatry global open science2024
Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents.
Article in Biological psychiatry global open science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Demographics change the relationships between socioeconomic status, white matter network organization, and cognition in children.Developmental cognitive neuroscience · 2026Article
- Neighborhood opportunity, white matter, and cognition in a large pediatric neuroimaging study.Translational psychiatry · 2026Article
- White matter reflects the childhood exposome.bioRxiv : the preprint server for biology · 2026Article
- Prenatal Adversity and Neonatal Brain Connectivity Relate to Emerging Executive Function at Age 2 Years.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Associations of neighborhood deprivation and household income during pregnancy on child externalizing and internalizing problems.Development and psychopathology · 2026Article
- Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The exposome and the developing adolescent brain: understanding mechanisms of neuroplasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Childhood Adversity Is Associated With Longitudinal White Matter Changes After Adulthood Trauma.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Neighborhood disadvantage and parenting predict longitudinal clustering of uncinate fasciculus microstructural integrity and clinical symptomatology in adolescents.Developmental cognitive neuroscience · 2024Article
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
Background: Neighborhood- or area-level socioeconomic disadvantage is associated with neural alterations across the life span. However, few studies have examined the effects of neighborhood disadvantage on white matter microstructure during adolescence, an important period of development that coincides with increased risk for psychopathology. Methods: In 200 adolescents (ages 13-20 years; 54.5% female, 4% nonbinary) recruited from 2 studies enriched for early adversity and depression, we examined whether neighborhood socioeconomic disadvantage derived from census tract data was related to white matter microstructure in several major white matter tracts. We also examined whether depressive symptoms and sex moderated these associations. Results: Greater neighborhood socioeconomic disadvantage was associated with lower fractional anisotropy (FA) in the left arcuate fasciculus (β = -0.24, false discovery rate [FDR]-corrected Conclusions: Greater neighborhood socioeconomic disadvantage, particularly poverty and educational attainment levels, was associated with lower FA in the arcuate fasciculus and uncinate fasciculus above and beyond the effects of family-level measures of socioeconomic status. These patterns were only observed in adolescents with low levels of depression, suggesting that we must be cautious about generalizing these findings to youths who struggle with mental health difficulties.
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