ArticlemedRxiv : the preprint server for health sciences2023
Network medicine-based epistasis detection in complex diseases: ready for quantum computing.
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Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
48 authors at 19 institutions in 10 countries.
Markus HoffmannChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Germany.
Julian M PoschenriederChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Germany.ORCID 0009-0004-5948-3892
Massimiliano IncudiniDipartimento di Informatica, Universit'a di Verona, Strada le Grazie 15 - 34137, Verona, Italy.ORCID 0000-0002-9389-5370
Sylvie BaierChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Germany.ORCID 0000-0002-9120-6279
Amelie FitzDepartment of Health Technology, Section for Bioinformatics, Technical University of Denmark, DTU, 2800 Kgs. Lyngby, Denmark.
Andreas MaierInstitute for Computational Systems Biology, University of Hamburg, Germany.ORCID 0000-0003-4408-0068
Michael HartungInstitute for Computational Systems Biology, University of Hamburg, Germany.ORCID 0000-0002-3992-0125
Christian HoffmannInstitute for Computational Systems Biology, University of Hamburg, Germany.ORCID 0009-0005-5352-9236
Nico TrummerChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Germany.ORCID 0000-0002-4639-0935
Klaudia AdamowiczInstitute for Computational Systems Biology, University of Hamburg, Germany.ORCID 0000-0002-9418-4386
Mario PiccianiComputational Mass Spectrometry, Technical University of Munich, Freising, Germany.
Evelyn ScheiblingChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Germany.
Maximilian V HarlChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Germany.ORCID 0000-0001-7522-5296
Ingmar LeschChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Germany.
Hunor FreyChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Germany.
Simon KayserChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Germany.
Paul WissenbergChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Germany.
Leon SchwartzChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Germany.ORCID 0000-0001-8621-4146
Leon HafnerChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Germany.ORCID 0000-0002-2705-1727
Aakriti AcharyaDivision Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics, Technische Universität Braunschweig and Hannover Medical School, Rebenring 56, 38106 Braunschweig, Germany.
Lena HacklInstitute for Computational Systems Biology, University of Hamburg, Germany.ORCID 0000-0001-7472-6224
Gordon GrabertDivision Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics, Technische Universität Braunschweig and Hannover Medical School, Rebenring 56, 38106 Braunschweig, Germany.ORCID 0000-0001-5499-9970
Sung-Gwon LeeNational Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD 20892, United States of America.
Gyuhyeok ChoDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju, Korea.ORCID 0000-0001-6785-616X
Matthew ClowardDepartment of Biology, Brigham Young University, Provo, UT, USA.ORCID 0000-0003-4775-5286
Jakub JankowskiNational Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD 20892, United States of America.
Hye Kyung LeeNational Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD 20892, United States of America.ORCID 0000-0002-7785-5942
Olga TsoyInstitute for Computational Systems Biology, University of Hamburg, Germany.ORCID 0000-0002-7592-2080
Nina WenkeInstitute for Computational Systems Biology, University of Hamburg, Germany.ORCID 0000-0002-8031-6878
Anders Gorm PedersenDepartment of Health Technology, Section for Bioinformatics, Technical University of Denmark, DTU, 2800 Kgs. Lyngby, Denmark.ORCID 0000-0001-9650-8965
Klaus BønnelykkeCopenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2003-1018
Antonio MandarinoInternational Centre for Theory of Quantum Technologies, University of Gdańsk, 80-309 Gdańsk, Poland.ORCID 0000-0003-3745-5204
Federico MelogranaBIO3 - Systems Genetics; GIGA-R Medical Genomics, University of Liège, Liège, Belgium.ORCID 0000-0001-9117-9242
Laura SchulzLeibniz Supercomputing Centre of the Bavarian Academy of Sciences and Humanities (LRZ), Garching b. München, Germany.ORCID 0000-0002-4702-3440
Héctor Climente-GonzálezRIKEN Center for Advanced Intelligence Project, Tokyo, Japan.
Mathias WilhelmComputational Mass Spectrometry, Technical University of Munich, Freising, Germany.ORCID 0000-0002-9224-3258
Luigi IapichinoLeibniz Supercomputing Centre of the Bavarian Academy of Sciences and Humanities (LRZ), Garching b. München, Germany.ORCID 0000-0003-3938-8973
Lars WienbrandtInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.ORCID 0000-0001-5685-2032
David EllinghausInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Kristel Van SteenBIO3 - Systems Genetics; GIGA-R Medical Genomics, University of Liège, Liège, Belgium.ORCID 0000-0001-9868-5033
Michele GrossiEuropean Organization for Nuclear Research (CERN), Geneva 1211, Switzerland.ORCID 0000-0003-1718-1314
Priscilla A FurthNational Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD 20892, United States of America.ORCID 0000-0003-3883-0715
Lothar HennighausenInstitute for Advanced Study (Lichtenbergstrasse 2 a, D-85748 Garching, Germany), Technical University of Munich, Germany.ORCID 0000-0001-8319-9841
Alessandra Di PierroDipartimento di Informatica, Universit'a di Verona, Strada le Grazie 15 - 34137, Verona, Italy.ORCID 0000-0003-4173-7941
Jan BaumbachInstitute for Computational Systems Biology, University of Hamburg, Germany.ORCID 0000-0002-0282-0462
Tim KacprowskiDivision Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics, Technische Universität Braunschweig and Hannover Medical School, Rebenring 56, 38106 Braunschweig, Germany.ORCID 0000-0002-5393-2413
Markus ListChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Germany.ORCID 0000-0002-0941-4168
David B BlumenthalDepartment Artificial Intelligence in Biomedical Engineering (AIBE), Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.ORCID 0000-0001-8651-750X
Technical University of Munich · DEUniversität Hamburg · DENational Institute of Diabetes and Digestive and Kidney Diseases · USMedizinische Hochschule Hannover · DEBavarian Academy of Sciences and Humanities · DEChristian-Albrechts-Universität zu Kiel · DEUniversity of Copenhagen · DKUniversity of Liège · BEUniversity of Verona · ITBrigham Young University · USChonnam National University · KREuropean Organization for Nuclear Research · CHFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGeorgetown University · USGwangju Institute of Science and Technology · KRInstitute for Advanced Study · DERIKEN Center for Advanced Intelligence Project · JPTechnical University of Denmark · DKUniversity of Gdańsk · PL
Funding
Wellcome Trust
Abstract
Most heritable diseases are polygenic. To comprehend the underlying genetic architecture, it is crucial to discover the clinically relevant epistatic interactions (EIs) between genomic single nucleotide polymorphisms (SNPs)
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What Socratic holds
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