Evidence map›Paper›PMID 38077044›Full record

ArticlebioRxiv : the preprint server for biology2024

Paradoxical dominant negative activity of an immunodeficiency-associated activating

Patsy R Tomlinson, Rachel Knox, Olga Perisic, Helen C Su, Gemma V Brierley, Roger L Williams, Robert K Semple

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Patsy R TomlinsonThe University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.
Rachel KnoxThe University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.
Olga PerisicMRC Laboratory of Molecular Biology, Cambridge, UK.
Helen C SuLaboratory of Clinical Immunology & Microbiology, Intramural Research Program, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5582-9110
Gemma V BrierleyDepartment of Comparative Biomedical Science, The Royal Veterinary College, London NW1 0TU, UK.ORCID 0000-0002-4600-9970
Roger L WilliamsMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0001-7754-4207
Robert K SempleThe University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.ORCID 0000-0001-6539-3069
University of Cambridge · GBMRC Laboratory of Molecular Biology · GBNational Institutes of Health · USRoyal Veterinary College · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

APDS2cancerimmunodeficiencyinsulin resistancephosphoinositide 3-kinasePIK3R1SHORT syndrome

Identifiers

PMID38077044
PMCPMC10705566
OpenAlexW4388299572

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.