Evidence map›Paper›PMID 38077061›Full record

ArticleResearch square2023

The L27 Domain of MPP7 enhances TAZ-YY1 Cooperation to Renew Muscle Stem Cells.

Anwen Shao, Joseph L Kissil, Chen-Ming Fan

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Anwen ShaoDepartment of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD 21218.
Joseph L KissilDepartment of Molecular Oncology, The H. Lee Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612.
Chen-Ming FanDepartment of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD 21218.ORCID https://orcid.org/0000-0003-3211-6617
Carnegie Institution for Science · USJohns Hopkins University · US

Funding

Muscle Stem Cell LineageR01AR060042 · NIAMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI FAN, CHEN-MING · 2010 to 2019
$3.5M
Integrin signaling in skeletal muscle regenerationR01AR071976 · NIAMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI FAN, CHEN-MING · 2017 to 2021
$1.8M
Proliferation competence of skeletal muscle stem cellsR01AR072644 · NIAMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI FAN, CHEN-MING · 2018 to 2022
$1.8M
NIAMS NIH HHS R01 AR060042NIAMS NIH HHS R01 AR071976NIAMS NIH HHS R01 AR072644
6 · The paper itself

Abstract

Stem cells regenerate differentiated cells to maintain and repair tissues and organs. They also replenish themselves, i.e. self-renewal, for the regenerative process to last a lifetime. How stem cells renew is of critical biological and medical significance. Here we use the skeletal muscle stem cell (MuSC) to study this process. Using a combination of genetic, molecular, and biochemical approaches, we show that MPP7, AMOT, and TAZ/YAP form a complex that activates a common set of target genes. Among these targets,

Identifiers

PMID38077061
PMCPMC10705706
OpenAlexW4389203100

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.