Evidence map›Paper›PMID 38077147›Full record

ArticleiScience2023

The hypoxia-inducible factor EPAS1 is required for spermatogonial stem cell function in regenerative conditions.

Ilana R Bernstein, Brett Nixon, Jess M Lyons, Katerina B Damyanova, Camila S De Oliveira, Nishani S Mabotuwana, Simone J Stanger, Gerard E Kaiko, Tan Hui Ying, Jon M Oatley and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Ilana R BernsteinPriority Research Centre for Reproductive Science, Discipline of Biological Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
Brett NixonPriority Research Centre for Reproductive Science, Discipline of Biological Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
Jess M LyonsPriority Research Centre for Reproductive Science, Discipline of Biological Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
Katerina B DamyanovaPriority Research Centre for Reproductive Science, Discipline of Biological Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
Camila S De OliveiraPriority Research Centre for Reproductive Science, Discipline of Biological Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
Nishani S MabotuwanaPriority Research Centre for Reproductive Science, Discipline of Biological Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
Simone J StangerPriority Research Centre for Reproductive Science, Discipline of Biological Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
Gerard E KaikoHunter Medical Research Institute, Immune Health Research Program, New Lambton Heights, NSW 2305, Australia.
Tan Hui YingHunter Medical Research Institute, Immune Health Research Program, New Lambton Heights, NSW 2305, Australia.
Jon M OatleySchool of Molecular Biosciences, Centre for Reproductive Biology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
Nicole M SkillenPriority Research Centre for Reproductive Science, Discipline of Biological Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
Alyssa J LochrinPriority Research Centre for Reproductive Science, Discipline of Biological Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
Jera L PetersPriority Research Centre for Reproductive Science, Discipline of Biological Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
Tessa LordPriority Research Centre for Reproductive Science, Discipline of Biological Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
University of Newcastle Australia · AUHunter Medical Research Institute · AUWashington State University · US

Funding

Mechanisms of stem cell specification in the male germlineR01HD101223 · NICHD · WASHINGTON STATE UNIVERSITY · PI OATLEY, JON M · 2020 to 2023
$2.0M
NICHD NIH HHS R01 HD101223
6 · The paper itself

Abstract

In this study we explored the role of hypoxia and the hypoxia-inducible transcription factor EPAS1 in regulating spermatogonial stem cell (SSC) function in the mouse testis. We have demonstrated that SSCs reside in hypoxic microenvironments in the testis through utilization of the oxygen-sensing probe pimonidazole, and by confirming the stable presence of EPAS1, which is degraded at >5% O

Indexed as

Biological sciencesCell biologyPhysiology

Identifiers

PMID38077147
PMCPMC10700845
OpenAlexW4388534301

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.