ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2023
Association of Novel Insulin Resistance Indices with Blood Pressure in New-Onset Hypertension and Elevated Blood Pressure Individuals: A Cross-Sectional Study.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07589374 (Correlation Between Carotid-Femoral Pulse Wave Velocity and Triglyceride-Glucose Index and Its Derived Metrics), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correlation Between Carotid-Femoral Pulse Wave Velocity and Triglyceride-Glucose Index and Its Derived Metrics
Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- The insulin resistance-systemic vascular resistance-isolated diastolic hypertension axis: a metabolic framework for an overlooked hypertension phenotype.Frontiers in cardiovascular medicine · 2026Review
- Article
- Association of metabolic score for insulin resistance and preeclampsia: a multicenter cohort study.Lipids in health and disease · 2025Article
- Prediction of Hypertension Risk in Patients with Fatty Liver Disease Using the Triglyceride-Glucose-Body Mass Index.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Insulin resistance (IR) has a bearing on blood pressure (BP). Nevertheless, research on the relationships between surrogates for IR and BP is limited. In this study, we investigate the associations of these novel IR indices with BP in new-onset hypertension (HTN) and elevated BP individuals. Methods: An overall sample of 55,381 adult subjects was included in Hebei General Hospital. BP and other clinical indicators were measured. Triglyceride glucose (TyG) index, TyG-waist circumference (TyG-WC), TyG-body mass index (TyG-BMI), TyG-waist to height ratio (TyG-WHtR), triglyceride-to-high-density lipoprotein-cholesterol ratio (TG/HDL-C) and metabolic score for IR (METS-IR) were collected as dependable surrogates for IR. Examinees were categorized into four groups based on BP levels. Those involved were classified as quartiles according to the levels of six surrogate IR indices. Logistic regression analysis was adopted to evaluate the impact of substitute IR indicators on BP. The receiver operating characteristic curve (ROC) analysis was performed to explore the predictive ability of the parameters on BP. Results: The incidence of elevated BP, stage 1 HTN and stage 2 HTN was 7.86%, 24.05% and 23.76%, respectively. As the levels of six substitute IR indices rose, so did the BP. In the logistic regression analysis, after full adjustment, all alternative IR indicators were independently related to both stage 1 HTN and stage 2 HTN. Except for TG/HDL-C, other substitute IR indices were strongly associated with elevated BP. ROC curves analysis suggested TyG-WC and TyG-WHtR outperformed other indicators with higher odd ratios and area under the curve (AUC) in all the participants. Conclusion: Increased substitute IR indices were significantly associated with elevated BP in new-onset HTN and elevated BP individuals. TyG-WC and TyG-WHtR could better predict elevated BP, stage 1 HTN and stage 2 HTN.
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