Evidence map›Paper›PMID 38084249›Full record

ArticleJournal of medical biochemistry2023

The effect of age and gender on HbA1c levels in adults without diabetes mellitus.

Şener Gülsen, Kahvecioğlu Esra Deniz, Can Başak, Gümüş Alper, Beyazıt Semih Yeşil, Evran Betül

Open access · diamondAbstract read
In one paragraph

Article in Journal of medical biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  4. Determining A1C Normal Values in Rhesus Macaques (Macaca mulatta).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
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  8. The Impact of Age and Sex on Fasting Plasma Glucose and Glycated Haemoglobin (HbA1c) in the Non-diabetes Population.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Şener GülsenBaşakşehir Çam and Sakura City Hospital, Department of Biochemistry, Istanbul, Turkey.
Kahvecioğlu Esra DenizBaşakşehir Çam and Sakura City Hospital, Department of Internal Medicine, Istanbul, Turkey.
Can BaşakBaşakşehir Çam and Sakura City Hospital, Department of Internal Medicine, Istanbul, Turkey.
Gümüş AlperBaşakşehir Çam and Sakura City Hospital, Department of Biochemistry, Istanbul, Turkey.
Beyazıt Semih YeşilBaşakşehir Çam and Sakura City Hospital, Department of Biochemistry, Istanbul, Turkey.
Evran BetülBaşakşehir Çam and Sakura City Hospital, Department of Biochemistry, Istanbul, Turkey.
Istanbul Metropolitan Municipality · TRİstanbul Başakşehir Çam ve Sakura Şehir Hastanesi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hemoglobin A1c (HbA1c) levels play an important role in diagnosing, screening, and monitoring the treatment of diabetes. Our study aims to determine whether a relationship exists between HbA1c levels and age and gender in Turkish adults who have not been diagnosed with diabetes. Methods: This retrospective study included 6776 Turkish adults with no known diabetes. Cross-sectional analyses of A1C levels were performed between different age and gender categories. In statistical analysis, t-test, linear regression analysis, one-way ANOVA analysis, and LSD post hoc were used. Results: HbA1c levels in the individuals examined by dividing into different age groups increased with age in all groups. In our study, HbA1c levels were significantly higher in males than females (p<0.001) in all groups, especially between the ages of 30-49, and were positively associated with age for males and females. There was a positive correlation between HbA1c and age in both mans and women aged 30-49 (P<0.05). In the HbA1c 6.5% group newly diagnosed with diabetes, HbA1c levels gradually decreased with age in both genders, and no significant effect of age on HbA1c level was detected (p>0.05). Conclusions: Our results showed that it is important to evaluate the effects of age and gender when using HbA1c levels in the diagnosis, screening, and treatment of diabetes, especially in young and middle-aged populations. Applying this situation to daily practice may reduce the misdiagnosis of diabetes in elderly patients, overtreatment of diabetes, and its associated risks.

Indexed as

agecorrelationdiabetes mellitusgenderHbA1c

Identifiers

PMID38084249
PMCPMC10710816
OpenAlexW4385068499

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.