Metformin × adverse events & safety

TrialJAMA2023

Metformin Plus Insulin for Preexisting Diabetes or Gestational Diabetes in Early Pregnancy: The MOMPOD Randomized Clinical Trial.

Kim A Boggess et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 831 people · 2023

Randomised comparison

Probably lowered pregnancy & neonatal

−37%−54% to −14%

Bigger than 7 in 10 on the map

As reported

OR 0.63, 95% CI 0.46–0.86

Range includes no effect

No clear effect on adverse events & safety

−14%−37% to +19%

Bigger than 4 in 10 for adverse events & safety

As reported

OR 0.86, 95% CI 0.63–1.19

Two numbers in the abstract

the abstract, start to end

the placebo group (adjusted odds ratio, 0.86 [95% CI 0.63-1.19]).

gestational age (adjusted odds ratio, 0.63 [95% CI, 0.46-0.86]) when

← favours treatmentfavours comparator →
could be chance
Adverse events & safety
OR 0.860.63–1.19
Pregnancy & neonatal
OR 0.630.46–0.86
MetforminPregnancy & neonatalAdverse events & safety

Metformin × adverse events & safetyharms?mixed

unlikelylikely
0.270.29 without it

Metformin × pregnancy & neonatalhelps?mixed

unlikelylikely
0.000.25 without it
← favours treatmentfavours comparator →
this papermore certainless certain
1 / 5

35 papers cite it

2023
2024
2025
2026
this paperpooled ittrialcites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 38085312