Evidence map›Paper›PMID 38089433›Full record

ArticleMaterials today. Bio2023

Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis.

Pei-Ru Jheng, Chia-Che Chiang, Jiunn-Horng Kang, Yu-Jui Fan, Kevin C-W Wu, Yan-Ting Chen, Jia-Wei Liang, Nima Bolouki, Jyh-Wei Lee, Jang-Hsing Hsieh and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Pei-Ru JhengGraduate Institute of Nanomedicine and Medical Engineering, Graduate Institute of Biomedical Materials and Tissue Engineering, Institute of Biomedical Optomechatronics, International Ph.D. Program in Biomedical Engineering, School of Biomedical Engineering, College of Biomedical Engineering, Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Chia-Che ChiangGraduate Institute of Nanomedicine and Medical Engineering, Graduate Institute of Biomedical Materials and Tissue Engineering, Institute of Biomedical Optomechatronics, International Ph.D. Program in Biomedical Engineering, School of Biomedical Engineering, College of Biomedical Engineering, Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Jiunn-Horng KangGraduate Institute of Nanomedicine and Medical Engineering, Graduate Institute of Biomedical Materials and Tissue Engineering, Institute of Biomedical Optomechatronics, International Ph.D. Program in Biomedical Engineering, School of Biomedical Engineering, College of Biomedical Engineering, Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Yu-Jui FanGraduate Institute of Nanomedicine and Medical Engineering, Graduate Institute of Biomedical Materials and Tissue Engineering, Institute of Biomedical Optomechatronics, International Ph.D. Program in Biomedical Engineering, School of Biomedical Engineering, College of Biomedical Engineering, Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Kevin C-W WuInstitute of Biomedical Engineering & Nanomedicine, National Health Research Institute, Keyan Road, Zhunan, Miaoli City, 350, Taiwan.
Yan-Ting ChenGraduate Institute of Nanomedicine and Medical Engineering, Graduate Institute of Biomedical Materials and Tissue Engineering, Institute of Biomedical Optomechatronics, International Ph.D. Program in Biomedical Engineering, School of Biomedical Engineering, College of Biomedical Engineering, Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Jia-Wei LiangGraduate Institute of Nanomedicine and Medical Engineering, Graduate Institute of Biomedical Materials and Tissue Engineering, Institute of Biomedical Optomechatronics, International Ph.D. Program in Biomedical Engineering, School of Biomedical Engineering, College of Biomedical Engineering, Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Nima BoloukiDepartment of Plasma Physics and Technology, Faculty of Science, Masaryk University, Brno, Czech Republic.
Jyh-Wei LeeCenter for Plasma and Thin Film Technologies, Ming Chi University of Technology, New Taipei City, Taiwan.
Jang-Hsing HsiehCenter for Plasma and Thin Film Technologies, Ming Chi University of Technology, New Taipei City, Taiwan.
Er-Yuan ChuangGraduate Institute of Nanomedicine and Medical Engineering, Graduate Institute of Biomedical Materials and Tissue Engineering, Institute of Biomedical Optomechatronics, International Ph.D. Program in Biomedical Engineering, School of Biomedical Engineering, College of Biomedical Engineering, Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Taipei Medical University · TWMing Chi University of Technology · TWMasaryk University · CZNational Health Research Institutes · TWTaipei Medical University Hospital · TWWan Fang Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new approach to treating vascular blockages has been developed to overcome the limitations of current thrombolytic therapies. This approach involves biosafety and multimodal plasma-derived theranostic platelet vesicle incorporating iron oxide constructed nano-propellers platformed technology that possesses fluorescent and magnetic features and manifold thrombus targeting modes. The platform is capable of being guided and visualized remotely to specifically target thrombi, and it can be activated using near-infrared phototherapy along with an actuated magnet for magnetotherapy. In a murine model of thrombus lesion, this proposed multimodal approach showed an approximately 80 % reduction in thrombus residues. Moreover, the new strategy not only improves thrombolysis but also boosts the rate of lysis, making it a promising candidate for time-sensitive thrombolytic therapy.

Indexed as

Cold atmospheric plasmaIron oxideMagnetotherapyPhototherapyPlatelet vesicleThrombolysis

Identifiers

PMID38089433
PMCPMC10711232
OpenAlexW4388996501

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.