ArticleSocial psychiatry and psychiatric epidemiology2024
Adverse outcome analysis in people at clinical high risk for psychosis: results from a 2-year Italian follow-up study.
Article in Social psychiatry and psychiatric epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of suicidal behaviour in adolescents and youth at ultra-high risk for psychosis: A systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Sex-specific clinical profiles and long-term outcomes in adolescents and young people at clinical high risk for psychosis: Findings from the PARMS program.European child & adolescent psychiatry · 2026Article
- The Mini-CAARMS: Development and Validation of a Short Version of the Comprehensive Assessment of AT Risk Mental States to Facilitate Preventive Psychiatry.Schizophrenia bulletin · 2026Article
- Mental health antecedents in first episode of psychosis: impact on prognosis across transitional age.European child & adolescent psychiatry · 2026Article
- Psychiatric Antecedents in Adolescents at Clinical High Risk for Psychosis: Insights from the "Parma At-Risk Mental States" Follow-up Program.Research on child and adolescent psychopathology · 2025Article
- Interpersonal difficulties and suicidal ideation in young people at clinical high-risk for psychosis and help-seeking clinical controls.Psychiatry research · 2025Article
- Clinical high risk for psychosis and service disengagement: Incidence and predictors across 2 years of follow-up.Early intervention in psychiatry · 2025Article
- Persistent negative symptoms in young people at clinical high risk of psychosis treated with an Italian early intervention program: a longitudinal study.European archives of psychiatry and clinical neuroscience · 2024Article
- Social network structure as a biopsychosocial suicide prevention target for young people at clinical high-risk for psychosis.Schizophrenia research · 2024Review
- Adverse outcome analysis in people at clinical high risk for psychosis: results from a 2-year Italian follow-up study.Social psychiatry and psychiatric epidemiology · 2024Article
- Antipsychotic Treatment in People at Clinical High Risk for Psychosis: A Narrative Review of Suggestions for Clinical Practice.Journal of clinical psychopharmacologyReview
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSince January 2016, the Parma Department of Mental Health (in Italy) developed a specialized care program for Early Intervention (EI) in individuals at Clinical High Risk for Psychosis (CHR-P). As unfavorable outcomes other than transition to psychosis were not systematically reported in the current literature (thereby compromising more sophisticated prognostic stratifications), the aims of this research were (1) to investigate adverse outcome indicators (i.e., service disengagement, psychosis transition, hospitalization, prolonged functioning impairment, prolonged persistence of CHR-P criteria, suicide attempts) in an Italian CHR-P population enrolled within a specialized EI service across a 2-year follow-up period, and (2) to examine their relevant associations with sociodemographic and clinical characteristics of the CHR-P total sample at baseline.
methodsAll participants were young CHR-P help-seekers aged 12-25 years. They completed the "Comprehensive Assessment of At-Risk Mental States" (CAARMS) and the Health of the Nation Outcome Scale (HoNOS). Both univariate and multivariate Cox regression analyses were performed.
results164 CHR-P individuals were enrolled in this study. Across the follow-up, 30 (18.0%) dropped out the EI program, 23 (14%) transitioned to psychosis, 24 (14.6%) were hospitalized, 23 (14%) had a prolonged persistence of CHR-P criteria and 54 (47%) showed prolonged impairment in socio-occupational functioning.
conclusionAs almost half of our participants did not functionally remit over time, sustained clinical attention for young CHR individuals people should be offered in the longer term, also to monitor unfavorable outcomes and to improve long-term prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.