Evidence map›Paper›PMID 38091504›Full record

ArticleBiochemistry2024

Screening and Characterization of Allosteric Small Molecules Targeting Bruton's Tyrosine Kinase.

Lauren E Kueffer, David Yin-Wei Lin, Neha Amatya, Joseph Serrenho, Raji E Joseph, Adam H Courtney, Amy H Andreotti

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lauren E KuefferRoy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.ORCID 0009-0001-7791-9301
David Yin-Wei LinRoy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.
Neha AmatyaRoy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.
Joseph SerrenhoDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Raji E JosephRoy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.
Adam H CourtneyDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Amy H AndreottiRoy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.ORCID 0000-0002-6952-7244
Iowa State University · USUniversity of Michigan · US

Funding

STRUCTURAL STUDIES OF A T CELL SPECIFIC TYROSINE KINASER01AI043957 · NIAID · IOWA STATE UNIVERSITY · PI AMY H ANDREOTTI, LESLIE JOAN BERG · 1999 to 2026
$9.5M
Mechanisms of ligand discrimination by the T cell signaling machineryR35GM146813 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Adam Courtney · 2022 to 2026
$1.9M
NIAID NIH HHS R01 AI043957NIGMS NIH HHS R35 GM146813
6 · The paper itself

Abstract

Bruton's Tyrosine Kinase (BTK) is a nonreceptor tyrosine kinase that belongs to the TEC family. Mutations in the

Indexed as

Protein-Tyrosine KinasesSignal TransductionAgammaglobulinaemia Tyrosine KinaseBinding SitesHumansMutationAgammaglobulinaemia Tyrosine KinaseProtein-Tyrosine Kinases

Identifiers

PMID38091504
PMCPMC12126845
OpenAlexW4389663704

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.