Evidence map›Paper›PMID 38093120›Full record

Trial reportEuropean journal of nutrition2024

Impact of dairy fat manipulation on endothelial function and lipid regulation in human aortic endothelial cells exposed to human plasma samples: an in vitro investigation from the RESET study.

Oonagh Markey, Alba Garcimartín, Dafni Vasilopoulou, Kirsty E Kliem, Colette C Fagan, David J Humphries, Susan Todd, David I Givens, Julie A Lovegrove, Kim G Jackson

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Oonagh MarkeyHugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6DZ, UK.
Alba GarcimartínHugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6DZ, UK.
Dafni VasilopoulouHugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6DZ, UK.
Kirsty E KliemDepartment of Animal Sciences, University of Reading, Reading, RG6 6AR, UK.
Colette C FaganHugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6DZ, UK.
David J HumphriesDepartment of Animal Sciences, University of Reading, Reading, RG6 6AR, UK.
Susan ToddDepartment of Mathematics and Statistics, University of Reading, Reading, RG6 6AX, UK.
David I GivensInstitute for Food, Nutrition, and Health, University of Reading, Reading, RG6 6AR, UK.
Julie A LovegroveHugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6DZ, UK.
Kim G JacksonHugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6DZ, UK. k.g.jackson@reading.ac.uk.ORCID http://orcid.org/0000-0002-0070-3203
University of Reading · GBLoughborough University · GBUniversidad Complutense de Madrid · ES

Funding

Medical Research Council MR/K020218/1
6 · The paper itself

Abstract

purposeLonger-term intake of fatty acid (FA)-modified dairy products (SFA-reduced, MUFA-enriched) was reported to attenuate postprandial endothelial function in humans, relative to conventional (control) dairy. Thus, we performed an in vitro study in human aortic endothelial cells (HAEC) to investigate mechanisms underlying the effects observed in vivo.

methodsThis sub-study was conducted within the framework of the RESET study, a 12-week randomised controlled crossover trial with FA-modified and control dairy diets. HAEC were incubated for 24 h with post-intervention plasma samples from eleven adults (age: 57.5 ± 6.0 years; BMI: 25.7 ± 2.7 kg/m

resultsRelative to control, HAEC incubation with plasma following the FA-modified treatment increased postprandial NOx production (P-interaction = 0.019), yet up-regulated relative E-selectin mRNA gene expression (P-interaction = 0.011). There was no impact on other genes measured.

conclusionIncubation of HAEC with human plasma collected after longer-term dairy fat manipulation had a beneficial impact on postprandial NOx production. Further ex vivo research is needed to understand the impact of partial replacement of SFA with unsaturated fatty acids in dairy foods on pathways involved in endothelial function.

Indexed as

Endothelial CellsFatty AcidsAdultCross-Over StudiesDairy ProductsDietDietary FatsFatty Acids, UnsaturatedHumansMiddle AgedPostprandial PeriodDietary FatsFatty AcidsFatty Acids, UnsaturatedCell adhesion moleculesDairy fatty acid manipulationHuman aortic endothelial cellsNitric oxideReal-time PCR

Identifiers

PMID38093120
PMCPMC10899290
OpenAlexW4389670777

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.