Evidence map›Paper›PMID 38095085›Full record

ArticleCirculation research2024

The Role of

David Y Chiang, Arie O Verkerk, Rachelle Victorio, Boris I Shneyer, Babet van der Vaart, Mariam Jouni, Nakul Narendran, Ashmita Kc, James R Sampognaro, Franki Vetrano-Olsen and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Brugada Syndrome: an exemplar for the genomic basis of sudden death.European journal of human genetics : EJHG · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Dysfunctional cardiomyocyte signalling and heart disease.Current opinion in cell biology · 2025
    Review
  8. Zebrafish as a Model System for Brugada Syndrome.Reviews in cardiovascular medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 4 countries.

David Y ChiangCardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C., R.V., N.N., A.K., J.R.S., F.V.-O., J.S.O., E.B., C.A.M.).ORCID 0000-0002-5883-6383
Arie O VerkerkDepartment of Experimental Cardiology, Heart Center (A.O.V., C.R.B.), Academic Medical Center, Amsterdam UMC, the Netherlands.ORCID 0000-0003-2140-834X
Rachelle VictorioCardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C., R.V., N.N., A.K., J.R.S., F.V.-O., J.S.O., E.B., C.A.M.).
Boris I ShneyerCell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, the Netherlands (B.I.S., B.v.d.V., A.A.).
Babet van der VaartCell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, the Netherlands (B.I.S., B.v.d.V., A.A.).ORCID 0000-0003-3534-6880
Mariam JouniDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL (M.J., D.A.S., P.W.B.).ORCID 0000-0002-6576-1922
Nakul NarendranCardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C., R.V., N.N., A.K., J.R.S., F.V.-O., J.S.O., E.B., C.A.M.).ORCID 0000-0002-6356-1433
Ashmita KcCardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C., R.V., N.N., A.K., J.R.S., F.V.-O., J.S.O., E.B., C.A.M.).ORCID 0000-0002-8831-5124
James R SampognaroCardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C., R.V., N.N., A.K., J.R.S., F.V.-O., J.S.O., E.B., C.A.M.).
Franki Vetrano-OlsenCardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C., R.V., N.N., A.K., J.R.S., F.V.-O., J.S.O., E.B., C.A.M.).
John S OhCardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C., R.V., N.N., A.K., J.R.S., F.V.-O., J.S.O., E.B., C.A.M.).
Eva BuysCardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C., R.V., N.N., A.K., J.R.S., F.V.-O., J.S.O., E.B., C.A.M.).
Berend de JongeDepartment of Medical Biology (B.d.J.), Academic Medical Center, Amsterdam UMC, the Netherlands.
Disheet A ShahDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL (M.J., D.A.S., P.W.B.).
Tuomas KiviniemiHeart Center, Turku University Hospital and University of Turku, Finland (T.K.).ORCID 0000-0002-0908-3741
Paul W BurridgeDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL (M.J., D.A.S., P.W.B.).ORCID 0000-0001-9616-0006
Connie R BezzinaDepartment of Experimental Cardiology, Heart Center (A.O.V., C.R.B.), Academic Medical Center, Amsterdam UMC, the Netherlands.ORCID 0000-0002-0633-3514
Anna AkhmanovaCell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, the Netherlands (B.I.S., B.v.d.V., A.A.).ORCID 0000-0002-9048-8614
Calum A MacRaeCardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.Y.C., R.V., N.N., A.K., J.R.S., F.V.-O., J.S.O., E.B., C.A.M.).ORCID 0000-0001-5181-2664
Brigham and Women's Hospital · USAmsterdam UMC Location University of Amsterdam · NLInstitute of Neurobiology · BGNorthwestern University · USTurku University Hospital · FI

Funding

A Community Zebrafish Resource for Modeling GWAS BiologyR24OD017870 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM, MACRAE, CALUM A. · 2014 to 2021
$6.3M
Partners Healthcare Training Program in Precision and Genomic MedicineT32HG010464 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI HEIDI L REHM, JORDAN W SMOLLER · 2019 to 2026
$3.1M
The Role of End-Binding Protein 2 and Microtubule Network in Inherited Cardiac ArrhythmiasK99HL161472 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHIANG, DAVID YI-ENG · 2022 to 2023
$336k
NHGRI NIH HHS T32 HG010464NHLBI NIH HHS K99 HL161472NIH HHS R24 OD017870
6 · The paper itself

Abstract

backgroundBrugada syndrome is associated with loss-of-function

methodsA

resultsVoltage mapping of

conclusionsGenetic ablation of

Indexed as

Brugada SyndromeInduced Pluripotent Stem CellsVoltage-Gated Sodium ChannelsAction PotentialsAnimalsGenome-Wide Association StudyHumansMicrotubule-Associated ProteinsMicrotubulesMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelTubulinZebrafishMAPRE2 protein, humanMicrotubule-Associated ProteinsNAV1.5 Voltage-Gated Sodium ChannelTubulinVoltage-Gated Sodium Channelsarrhythmias, cardiacelectrophysiologymicrotubulessodium channelszebrafish

Identifiers

PMID38095085
PMCPMC11889334
OpenAlexW4389742478

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.