Evidence map›Paper›PMID 38097781›Full record

ArticleScientific reports2023

Association of high LDL concentrations with erectile dysfunction from a Mendelian randomization study.

Quan Zhu, Yao Tan, Xuyan Zou, Liqing Lu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 73% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Quan Zhu *Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Yao Tan *Department of Ophthalmology, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China.
Xuyan ZouThe First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Liqing LuXiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Liqing1992@csu.edu.cn.
Central South University · CNFirst Affiliated Hospital of Jinan University · CNThird Xiangya Hospital · CNXiangya Hospital Central South University · CN

Funding

Hunan Provincial Natural Science Foundation-Youth Fund Project 2023JJ40972Hunan Provincial Natural Science Foundation-Youth Fund Project 2023JJ41029
6 · The paper itself

Abstract

Lipid metabolism plays a key role in erectile dysfunction. Our purpose was to evaluate the influence of lipid-lowering drugs on erectile dysfunction employing a two-sample Mendelian randomization (MR) study. Genetic instruments were employed to represent the exposure of lipid-lowering drugs. Inverse variance-weighted MR (IVWMR) was employed to calculate the estimation of effects. IVW-MR analysis showed that the positive relationship between the expression of HMGCR and the risk of erectile dysfunction (odds ratio [OR] = 1.27, 95% confidence interval [CI] 1.03-1.57; p = 0.028). No significant relationship was detected between NPC1L1, PSK9 expression and erectile dysfunction. This MR study suggested that HMGCR inhibitors are a more desirable treatment modality for patients with ED.

Indexed as

Erectile DysfunctionGenome-Wide Association StudyHumansHypolipidemic AgentsLipid MetabolismLipidsMaleMendelian Randomization AnalysisPolymorphism, Single NucleotideHypolipidemic AgentsLipids

Identifiers

PMID38097781
PMCPMC10721885
OpenAlexW4389726511

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.